Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensive spectro...

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Autores principales: Zhang, Qi-Qi, Hu, Kun, Sun, Han-Dong, Puno, Pema-Tenzin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076471/
https://www.ncbi.nlm.nih.gov/pubmed/37020130
http://dx.doi.org/10.1007/s13659-023-00376-1
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author Zhang, Qi-Qi
Hu, Kun
Sun, Han-Dong
Puno, Pema-Tenzin
author_facet Zhang, Qi-Qi
Hu, Kun
Sun, Han-Dong
Puno, Pema-Tenzin
author_sort Zhang, Qi-Qi
collection PubMed
description Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E–H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00376-1.
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spelling pubmed-100764712023-04-07 Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea Zhang, Qi-Qi Hu, Kun Sun, Han-Dong Puno, Pema-Tenzin Nat Prod Bioprospect Original Article Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E–H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00376-1. Springer Nature Singapore 2023-04-06 /pmc/articles/PMC10076471/ /pubmed/37020130 http://dx.doi.org/10.1007/s13659-023-00376-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Zhang, Qi-Qi
Hu, Kun
Sun, Han-Dong
Puno, Pema-Tenzin
Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea
title Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea
title_full Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea
title_fullStr Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea
title_full_unstemmed Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea
title_short Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea
title_sort four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of kadsura coccinea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076471/
https://www.ncbi.nlm.nih.gov/pubmed/37020130
http://dx.doi.org/10.1007/s13659-023-00376-1
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