Sustained Response to Eculizumab in a Patient With COVID-19–Associated Acute Thrombotic Microangiopathy of the Allograft Kidney: A Case Report

Acute thrombotic microangiopathy (TMA) developing in association with SARS-CoV-2 infection is a rare but recognized phenomenon in native kidneys. In the allograft kidney, a diagnosis of TMA has a broad etiologic differential, including antibody-mediated rejection and recurrent and de novo causes of...

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Autores principales: Rehman, Shehzad, de Mattos, Angelo, Stack, Megan, Norman, Douglas, Zapata, Sarah, Wang, Pei Li, Mansoor, Abdul Hai, Kung, Vanderlene, Andeen, Nicole K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076506/
https://www.ncbi.nlm.nih.gov/pubmed/37105825
http://dx.doi.org/10.1016/j.transproceed.2023.03.072
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author Rehman, Shehzad
de Mattos, Angelo
Stack, Megan
Norman, Douglas
Zapata, Sarah
Wang, Pei Li
Mansoor, Abdul Hai
Kung, Vanderlene
Andeen, Nicole K.
author_facet Rehman, Shehzad
de Mattos, Angelo
Stack, Megan
Norman, Douglas
Zapata, Sarah
Wang, Pei Li
Mansoor, Abdul Hai
Kung, Vanderlene
Andeen, Nicole K.
author_sort Rehman, Shehzad
collection PubMed
description Acute thrombotic microangiopathy (TMA) developing in association with SARS-CoV-2 infection is a rare but recognized phenomenon in native kidneys. In the allograft kidney, a diagnosis of TMA has a broad etiologic differential, including antibody-mediated rejection and recurrent and de novo causes of TMA that affect the native kidney. Prior case reports have described plasma exchange or eculizumab use in patients with COVID-19–associated TMA. Herein, we describe the course of a kidney transplant patient with COVID-19–associated TMA with response to eculizumab that was sustained after medication withdrawal and review the literature on COVID-19–associated TMA of the allograft kidney.
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spelling pubmed-100765062023-04-06 Sustained Response to Eculizumab in a Patient With COVID-19–Associated Acute Thrombotic Microangiopathy of the Allograft Kidney: A Case Report Rehman, Shehzad de Mattos, Angelo Stack, Megan Norman, Douglas Zapata, Sarah Wang, Pei Li Mansoor, Abdul Hai Kung, Vanderlene Andeen, Nicole K. Transplant Proc Article Acute thrombotic microangiopathy (TMA) developing in association with SARS-CoV-2 infection is a rare but recognized phenomenon in native kidneys. In the allograft kidney, a diagnosis of TMA has a broad etiologic differential, including antibody-mediated rejection and recurrent and de novo causes of TMA that affect the native kidney. Prior case reports have described plasma exchange or eculizumab use in patients with COVID-19–associated TMA. Herein, we describe the course of a kidney transplant patient with COVID-19–associated TMA with response to eculizumab that was sustained after medication withdrawal and review the literature on COVID-19–associated TMA of the allograft kidney. Elsevier Inc. 2023-04-06 /pmc/articles/PMC10076506/ /pubmed/37105825 http://dx.doi.org/10.1016/j.transproceed.2023.03.072 Text en © 2023 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rehman, Shehzad
de Mattos, Angelo
Stack, Megan
Norman, Douglas
Zapata, Sarah
Wang, Pei Li
Mansoor, Abdul Hai
Kung, Vanderlene
Andeen, Nicole K.
Sustained Response to Eculizumab in a Patient With COVID-19–Associated Acute Thrombotic Microangiopathy of the Allograft Kidney: A Case Report
title Sustained Response to Eculizumab in a Patient With COVID-19–Associated Acute Thrombotic Microangiopathy of the Allograft Kidney: A Case Report
title_full Sustained Response to Eculizumab in a Patient With COVID-19–Associated Acute Thrombotic Microangiopathy of the Allograft Kidney: A Case Report
title_fullStr Sustained Response to Eculizumab in a Patient With COVID-19–Associated Acute Thrombotic Microangiopathy of the Allograft Kidney: A Case Report
title_full_unstemmed Sustained Response to Eculizumab in a Patient With COVID-19–Associated Acute Thrombotic Microangiopathy of the Allograft Kidney: A Case Report
title_short Sustained Response to Eculizumab in a Patient With COVID-19–Associated Acute Thrombotic Microangiopathy of the Allograft Kidney: A Case Report
title_sort sustained response to eculizumab in a patient with covid-19–associated acute thrombotic microangiopathy of the allograft kidney: a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076506/
https://www.ncbi.nlm.nih.gov/pubmed/37105825
http://dx.doi.org/10.1016/j.transproceed.2023.03.072
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