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The functional change of the P2X7R containing the Ala(348) to Thr polymorphism is associated with the pathogenesis of gout

Our previous study has shown that ATP action on P2X7R could be the second signal to induce the onset of gouty arthritis. However, the functional changes of P2X7R single nucleotide polymorphisms (SNPs) on the effects of ATP-P2X7R-IL-1β signaling pathway and uric acid remained unknown. We aimed to inv...

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Detalles Bibliográficos
Autores principales:	Li, Man-Yun, Fang, Xuan, Ma, Yan, Pan, Xian-Yang, Dai, Xiao-Juan, Li, Xiao-Mei, Li, Xiao-Ling, Wang, Yi-Ping, Tao, Jin-Hui, Li, Xiang-Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076518/ https://www.ncbi.nlm.nih.gov/pubmed/37020014 http://dx.doi.org/10.1038/s41598-023-32365-2

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