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Ovarian dysfunction in women with Turner syndrome

Ovarian dysfunction is one of the most common features of women with Turner syndrome. In these women, oocyte apoptosis is markedly accelerated from the early stage of fetal life. Reduction in the number of germ cells disturbs primordial follicle development and thereby leads to the formation of stre...

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Autor principal: Fukami, Maki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076527/
https://www.ncbi.nlm.nih.gov/pubmed/37033245
http://dx.doi.org/10.3389/fendo.2023.1160258
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author Fukami, Maki
author_facet Fukami, Maki
author_sort Fukami, Maki
collection PubMed
description Ovarian dysfunction is one of the most common features of women with Turner syndrome. In these women, oocyte apoptosis is markedly accelerated from the early stage of fetal life. Reduction in the number of germ cells disturbs primordial follicle development and thereby leads to the formation of streak gonads. There are three possible causes of accelerated germ cell loss in 45,X ovaries. First, chromosomal pairing failure due to X chromosomal aneuploidy is believed to induce meiotic arrest. Indeed, it has been suggested that the dosage of the X chromosome is more critical for the survival of the oocytes than for other cells in the ovary. Second, impaired coupling between oocytes and granulosa cells may also contribute to germ cell apoptosis. Previous studies have shown that 45,X ovaries may tend to lose tight junctions which are essential for intercellular interactions. Lastly, ovarian dysfunction in women with Turner syndrome is partly attributable to the reduced dosage of several genes on the X chromosome. Specifically, BMP15, PGRMC1, and some other genes on the X chromosome have been implicated in ovarian function. Further studies on the mechanisms of ovarian dysfunction are necessary to improve the reproductive outcomes of women with Turner syndrome.
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spelling pubmed-100765272023-04-07 Ovarian dysfunction in women with Turner syndrome Fukami, Maki Front Endocrinol (Lausanne) Endocrinology Ovarian dysfunction is one of the most common features of women with Turner syndrome. In these women, oocyte apoptosis is markedly accelerated from the early stage of fetal life. Reduction in the number of germ cells disturbs primordial follicle development and thereby leads to the formation of streak gonads. There are three possible causes of accelerated germ cell loss in 45,X ovaries. First, chromosomal pairing failure due to X chromosomal aneuploidy is believed to induce meiotic arrest. Indeed, it has been suggested that the dosage of the X chromosome is more critical for the survival of the oocytes than for other cells in the ovary. Second, impaired coupling between oocytes and granulosa cells may also contribute to germ cell apoptosis. Previous studies have shown that 45,X ovaries may tend to lose tight junctions which are essential for intercellular interactions. Lastly, ovarian dysfunction in women with Turner syndrome is partly attributable to the reduced dosage of several genes on the X chromosome. Specifically, BMP15, PGRMC1, and some other genes on the X chromosome have been implicated in ovarian function. Further studies on the mechanisms of ovarian dysfunction are necessary to improve the reproductive outcomes of women with Turner syndrome. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076527/ /pubmed/37033245 http://dx.doi.org/10.3389/fendo.2023.1160258 Text en Copyright © 2023 Fukami https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Fukami, Maki
Ovarian dysfunction in women with Turner syndrome
title Ovarian dysfunction in women with Turner syndrome
title_full Ovarian dysfunction in women with Turner syndrome
title_fullStr Ovarian dysfunction in women with Turner syndrome
title_full_unstemmed Ovarian dysfunction in women with Turner syndrome
title_short Ovarian dysfunction in women with Turner syndrome
title_sort ovarian dysfunction in women with turner syndrome
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076527/
https://www.ncbi.nlm.nih.gov/pubmed/37033245
http://dx.doi.org/10.3389/fendo.2023.1160258
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