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The little brain and the seahorse: Cerebellar-hippocampal interactions
There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors. Acute and chronic manipulations, simultaneous recordings, and imaging studies together indicate co...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076554/ https://www.ncbi.nlm.nih.gov/pubmed/37034014 http://dx.doi.org/10.3389/fnsys.2023.1158492 |
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author | Froula, Jessica M. Hastings, Shayne D. Krook-Magnuson, Esther |
author_facet | Froula, Jessica M. Hastings, Shayne D. Krook-Magnuson, Esther |
author_sort | Froula, Jessica M. |
collection | PubMed |
description | There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors. Acute and chronic manipulations, simultaneous recordings, and imaging studies together indicate coordinated coactivation and a bidirectional functional connectivity relevant for various physiological functions, including spatiotemporal processing. This bidirectional functional connectivity is likely supported by multiple circuit paths. It is also important in temporal lobe epilepsy: the cerebellum is impacted by seizures and epilepsy, and modulation of cerebellar circuitry can be an effective strategy to inhibit hippocampal seizures. This review highlights some of the recent key hippobellum literature. |
format | Online Article Text |
id | pubmed-10076554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100765542023-04-07 The little brain and the seahorse: Cerebellar-hippocampal interactions Froula, Jessica M. Hastings, Shayne D. Krook-Magnuson, Esther Front Syst Neurosci Neuroscience There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors. Acute and chronic manipulations, simultaneous recordings, and imaging studies together indicate coordinated coactivation and a bidirectional functional connectivity relevant for various physiological functions, including spatiotemporal processing. This bidirectional functional connectivity is likely supported by multiple circuit paths. It is also important in temporal lobe epilepsy: the cerebellum is impacted by seizures and epilepsy, and modulation of cerebellar circuitry can be an effective strategy to inhibit hippocampal seizures. This review highlights some of the recent key hippobellum literature. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076554/ /pubmed/37034014 http://dx.doi.org/10.3389/fnsys.2023.1158492 Text en Copyright © 2023 Froula, Hastings and Krook-Magnuson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Froula, Jessica M. Hastings, Shayne D. Krook-Magnuson, Esther The little brain and the seahorse: Cerebellar-hippocampal interactions |
title | The little brain and the seahorse: Cerebellar-hippocampal interactions |
title_full | The little brain and the seahorse: Cerebellar-hippocampal interactions |
title_fullStr | The little brain and the seahorse: Cerebellar-hippocampal interactions |
title_full_unstemmed | The little brain and the seahorse: Cerebellar-hippocampal interactions |
title_short | The little brain and the seahorse: Cerebellar-hippocampal interactions |
title_sort | little brain and the seahorse: cerebellar-hippocampal interactions |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076554/ https://www.ncbi.nlm.nih.gov/pubmed/37034014 http://dx.doi.org/10.3389/fnsys.2023.1158492 |
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