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The little brain and the seahorse: Cerebellar-hippocampal interactions

There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors. Acute and chronic manipulations, simultaneous recordings, and imaging studies together indicate co...

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Autores principales: Froula, Jessica M., Hastings, Shayne D., Krook-Magnuson, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076554/
https://www.ncbi.nlm.nih.gov/pubmed/37034014
http://dx.doi.org/10.3389/fnsys.2023.1158492
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author Froula, Jessica M.
Hastings, Shayne D.
Krook-Magnuson, Esther
author_facet Froula, Jessica M.
Hastings, Shayne D.
Krook-Magnuson, Esther
author_sort Froula, Jessica M.
collection PubMed
description There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors. Acute and chronic manipulations, simultaneous recordings, and imaging studies together indicate coordinated coactivation and a bidirectional functional connectivity relevant for various physiological functions, including spatiotemporal processing. This bidirectional functional connectivity is likely supported by multiple circuit paths. It is also important in temporal lobe epilepsy: the cerebellum is impacted by seizures and epilepsy, and modulation of cerebellar circuitry can be an effective strategy to inhibit hippocampal seizures. This review highlights some of the recent key hippobellum literature.
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spelling pubmed-100765542023-04-07 The little brain and the seahorse: Cerebellar-hippocampal interactions Froula, Jessica M. Hastings, Shayne D. Krook-Magnuson, Esther Front Syst Neurosci Neuroscience There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors. Acute and chronic manipulations, simultaneous recordings, and imaging studies together indicate coordinated coactivation and a bidirectional functional connectivity relevant for various physiological functions, including spatiotemporal processing. This bidirectional functional connectivity is likely supported by multiple circuit paths. It is also important in temporal lobe epilepsy: the cerebellum is impacted by seizures and epilepsy, and modulation of cerebellar circuitry can be an effective strategy to inhibit hippocampal seizures. This review highlights some of the recent key hippobellum literature. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076554/ /pubmed/37034014 http://dx.doi.org/10.3389/fnsys.2023.1158492 Text en Copyright © 2023 Froula, Hastings and Krook-Magnuson. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Froula, Jessica M.
Hastings, Shayne D.
Krook-Magnuson, Esther
The little brain and the seahorse: Cerebellar-hippocampal interactions
title The little brain and the seahorse: Cerebellar-hippocampal interactions
title_full The little brain and the seahorse: Cerebellar-hippocampal interactions
title_fullStr The little brain and the seahorse: Cerebellar-hippocampal interactions
title_full_unstemmed The little brain and the seahorse: Cerebellar-hippocampal interactions
title_short The little brain and the seahorse: Cerebellar-hippocampal interactions
title_sort little brain and the seahorse: cerebellar-hippocampal interactions
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076554/
https://www.ncbi.nlm.nih.gov/pubmed/37034014
http://dx.doi.org/10.3389/fnsys.2023.1158492
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