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Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children

In recent years, the prevalence of diabetes in China has significantly increased, and glibenclamide is widely used as a basic hypoglycemic drug in China's primary clinical practice. There are many left-behind children in the grass-roots areas in China and various dangerous incidents of children...

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Detalles Bibliográficos
Autores principales: Song, Chunlan, Jia, Wanyu, Shi, Shengli, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076595/
https://www.ncbi.nlm.nih.gov/pubmed/37035625
http://dx.doi.org/10.3389/fnbeh.2023.1085258
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author Song, Chunlan
Jia, Wanyu
Shi, Shengli
Li, Peng
author_facet Song, Chunlan
Jia, Wanyu
Shi, Shengli
Li, Peng
author_sort Song, Chunlan
collection PubMed
description In recent years, the prevalence of diabetes in China has significantly increased, and glibenclamide is widely used as a basic hypoglycemic drug in China's primary clinical practice. There are many left-behind children in the grass-roots areas in China and various dangerous incidents of children taking drugs by mistake continue to occur. This article reports a case of cerebral edema and fatal cerebral hernia caused by hypoglycemia induced by mistakenly ingesting glibenclamide in a child. This is the first reported case in China of a child who died from brain herniation caused by accidental administration of glibenclamide. This case reminded that clinicians must comprehensively consider the cause of convulsions and coma in children with unknown causes, ask the history in detail and cannot ignore the risk of hypoglycemic convulsions and coma. When hypoglycemic is detected, high concentration of glucose should be given promptly to normalize blood glucose. When dealing with unexplained convulsions and comatose children, clinical pediatricians must be alert to the possibility of accidental medication.
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spelling pubmed-100765952023-04-07 Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children Song, Chunlan Jia, Wanyu Shi, Shengli Li, Peng Front Behav Neurosci Behavioral Neuroscience In recent years, the prevalence of diabetes in China has significantly increased, and glibenclamide is widely used as a basic hypoglycemic drug in China's primary clinical practice. There are many left-behind children in the grass-roots areas in China and various dangerous incidents of children taking drugs by mistake continue to occur. This article reports a case of cerebral edema and fatal cerebral hernia caused by hypoglycemia induced by mistakenly ingesting glibenclamide in a child. This is the first reported case in China of a child who died from brain herniation caused by accidental administration of glibenclamide. This case reminded that clinicians must comprehensively consider the cause of convulsions and coma in children with unknown causes, ask the history in detail and cannot ignore the risk of hypoglycemic convulsions and coma. When hypoglycemic is detected, high concentration of glucose should be given promptly to normalize blood glucose. When dealing with unexplained convulsions and comatose children, clinical pediatricians must be alert to the possibility of accidental medication. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076595/ /pubmed/37035625 http://dx.doi.org/10.3389/fnbeh.2023.1085258 Text en Copyright © 2023 Song, Jia, Shi and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Song, Chunlan
Jia, Wanyu
Shi, Shengli
Li, Peng
Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children
title Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children
title_full Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children
title_fullStr Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children
title_full_unstemmed Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children
title_short Case report: Fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children
title_sort case report: fatal cerebral herniation caused by hypoglycemic due to mistaking glibenclamide in children
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076595/
https://www.ncbi.nlm.nih.gov/pubmed/37035625
http://dx.doi.org/10.3389/fnbeh.2023.1085258
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