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Association of thiamine administration and prognosis in critically ill patients with heart failure

Background: Thiamine deficiency is common in patients with heart failure, and thiamine supplement can benefit these patients. However, the association between thiamine administration and prognosis among critically ill patients with heart failure remains unclear. Thus, this study aims to prove the su...

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Autores principales: Yang, Rui, Huang, Jiasheng, Zhao, Yumei, Wang, Jia, Niu, Dongdong, Ye, Enlin, Yue, Suru, Hou, Xuefei, Cui, Lili, Wu, Jiayuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076601/
https://www.ncbi.nlm.nih.gov/pubmed/37033650
http://dx.doi.org/10.3389/fphar.2023.1162797
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author Yang, Rui
Huang, Jiasheng
Zhao, Yumei
Wang, Jia
Niu, Dongdong
Ye, Enlin
Yue, Suru
Hou, Xuefei
Cui, Lili
Wu, Jiayuan
author_facet Yang, Rui
Huang, Jiasheng
Zhao, Yumei
Wang, Jia
Niu, Dongdong
Ye, Enlin
Yue, Suru
Hou, Xuefei
Cui, Lili
Wu, Jiayuan
author_sort Yang, Rui
collection PubMed
description Background: Thiamine deficiency is common in patients with heart failure, and thiamine supplement can benefit these patients. However, the association between thiamine administration and prognosis among critically ill patients with heart failure remains unclear. Thus, this study aims to prove the survival benefit of thiamine use in critically ill patients with heart failure. Methods: A retrospective cohort analysis was performed on the basis of the Medical Information Mart of Intensive Care-Ⅳ database. Critically ill patients with heart failure were divided into the thiamine and non-thiamine groups depending on whether they had received thiamine therapy or not during hospitalization. The association between thiamine supplement and in-hospital mortality was assessed by using the Kaplan−Meier (KM) method and Cox proportional hazard models. A 1:1 nearest propensity-score matching (PSM) and propensity score-based inverse probability of treatment weighting (IPW) were also performed to ensure the robustness of the findings. Results: A total of 7,021 patients were included in this study, with 685 and 6,336 in the thiamine and non-thiamine groups, respectively. The kaplan−meier survival curves indicated that the thiamine group had a lower in-hospital mortality than the none-thiamine group. After adjusting for various confounders, the Cox regression models showed significant beneficial effects of thiamine administration on in-hospital mortality among critically ill patients with heart failure with a hazard ratio of 0.78 (95% confidence interval: 0.67–0.89) in the fully adjusted model. propensity-score matching and probability of treatment weighting analyses also achieved consistent results. Conclusion: Thiamine supplement is associated with a decreased risk of in-hospital mortality in critically ill patients with heart failure who are admitted to the ICU. Further multicenter and well-designed randomized controlled trials with large sample sizes are necessary to validate this finding.
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spelling pubmed-100766012023-04-07 Association of thiamine administration and prognosis in critically ill patients with heart failure Yang, Rui Huang, Jiasheng Zhao, Yumei Wang, Jia Niu, Dongdong Ye, Enlin Yue, Suru Hou, Xuefei Cui, Lili Wu, Jiayuan Front Pharmacol Pharmacology Background: Thiamine deficiency is common in patients with heart failure, and thiamine supplement can benefit these patients. However, the association between thiamine administration and prognosis among critically ill patients with heart failure remains unclear. Thus, this study aims to prove the survival benefit of thiamine use in critically ill patients with heart failure. Methods: A retrospective cohort analysis was performed on the basis of the Medical Information Mart of Intensive Care-Ⅳ database. Critically ill patients with heart failure were divided into the thiamine and non-thiamine groups depending on whether they had received thiamine therapy or not during hospitalization. The association between thiamine supplement and in-hospital mortality was assessed by using the Kaplan−Meier (KM) method and Cox proportional hazard models. A 1:1 nearest propensity-score matching (PSM) and propensity score-based inverse probability of treatment weighting (IPW) were also performed to ensure the robustness of the findings. Results: A total of 7,021 patients were included in this study, with 685 and 6,336 in the thiamine and non-thiamine groups, respectively. The kaplan−meier survival curves indicated that the thiamine group had a lower in-hospital mortality than the none-thiamine group. After adjusting for various confounders, the Cox regression models showed significant beneficial effects of thiamine administration on in-hospital mortality among critically ill patients with heart failure with a hazard ratio of 0.78 (95% confidence interval: 0.67–0.89) in the fully adjusted model. propensity-score matching and probability of treatment weighting analyses also achieved consistent results. Conclusion: Thiamine supplement is associated with a decreased risk of in-hospital mortality in critically ill patients with heart failure who are admitted to the ICU. Further multicenter and well-designed randomized controlled trials with large sample sizes are necessary to validate this finding. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076601/ /pubmed/37033650 http://dx.doi.org/10.3389/fphar.2023.1162797 Text en Copyright © 2023 Yang, Huang, Zhao, Wang, Niu, Ye, Yue, Hou, Cui and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Yang, Rui
Huang, Jiasheng
Zhao, Yumei
Wang, Jia
Niu, Dongdong
Ye, Enlin
Yue, Suru
Hou, Xuefei
Cui, Lili
Wu, Jiayuan
Association of thiamine administration and prognosis in critically ill patients with heart failure
title Association of thiamine administration and prognosis in critically ill patients with heart failure
title_full Association of thiamine administration and prognosis in critically ill patients with heart failure
title_fullStr Association of thiamine administration and prognosis in critically ill patients with heart failure
title_full_unstemmed Association of thiamine administration and prognosis in critically ill patients with heart failure
title_short Association of thiamine administration and prognosis in critically ill patients with heart failure
title_sort association of thiamine administration and prognosis in critically ill patients with heart failure
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076601/
https://www.ncbi.nlm.nih.gov/pubmed/37033650
http://dx.doi.org/10.3389/fphar.2023.1162797
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