Competing interests during the key N-glycosylation of 6-chloro-7-deaza-7-iodopurine for the synthesis of 7-deaza-2′-methyladenosine using Vorbrüggen conditions

A short 3-step synthesis of the antiviral agent 7DMA is described herein. The nature of a major by-product formed during the key N-glycosylation of 6-chloro-7-deaza-7-iodopurine with perbenzoylated 2-methyl-ribose under Vorbrüggen conditions was also investigated. Spectroscopic analyses support that...

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Detalles Bibliográficos
Autores principales: Naciuk, Fabrício Fredo, Nascimento, Andrey Fabricio Ziem, Rocha, Rebeca Paiva Froes, Rustiguel, Joane Kathelen, Coimbra, Lais Durço, Marques, Rafael Elias, Bruder, Marjorie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076608/
https://www.ncbi.nlm.nih.gov/pubmed/37035111
http://dx.doi.org/10.3389/fchem.2023.1163486

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