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Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training
Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial hypertension. Aerobic physical training induc...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076612/ https://www.ncbi.nlm.nih.gov/pubmed/37035672 http://dx.doi.org/10.3389/fphys.2023.1148146 |
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author | Drummond, Filipe Rios Leite, Luciano Bernardes de Miranda, Denise Coutinho Drummond, Lucas Rios Lavorato, Victor Neiva Soares, Leôncio Lopes Neves, Clóvis Andrade Natali, Antônio José |
author_facet | Drummond, Filipe Rios Leite, Luciano Bernardes de Miranda, Denise Coutinho Drummond, Lucas Rios Lavorato, Victor Neiva Soares, Leôncio Lopes Neves, Clóvis Andrade Natali, Antônio José |
author_sort | Drummond, Filipe Rios |
collection | PubMed |
description | Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial hypertension. Aerobic physical training induces skeletal muscle adaptations via reduced inflammation, improved anabolic processes, decreased hypoxia and regulation of mitochondrial function. These benefits improve physical exertion tolerance and quality of life in patients with pulmonary arterial hypertension. However, the mechanisms underlying the therapeutic potential of aerobic exercise to skeletal muscle disfunctions in patients with pulmonary arterial hypertension are not well understood yet. This minireview highlights the pathways involved in skeletal muscle adaptations to aerobic exercise training in patients with pulmonary arterial hypertension. |
format | Online Article Text |
id | pubmed-10076612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100766122023-04-07 Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training Drummond, Filipe Rios Leite, Luciano Bernardes de Miranda, Denise Coutinho Drummond, Lucas Rios Lavorato, Victor Neiva Soares, Leôncio Lopes Neves, Clóvis Andrade Natali, Antônio José Front Physiol Physiology Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial hypertension. Aerobic physical training induces skeletal muscle adaptations via reduced inflammation, improved anabolic processes, decreased hypoxia and regulation of mitochondrial function. These benefits improve physical exertion tolerance and quality of life in patients with pulmonary arterial hypertension. However, the mechanisms underlying the therapeutic potential of aerobic exercise to skeletal muscle disfunctions in patients with pulmonary arterial hypertension are not well understood yet. This minireview highlights the pathways involved in skeletal muscle adaptations to aerobic exercise training in patients with pulmonary arterial hypertension. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076612/ /pubmed/37035672 http://dx.doi.org/10.3389/fphys.2023.1148146 Text en Copyright © 2023 Drummond, Leite, de Miranda, Drummond, Lavorato, Soares, Neves and Natali. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Drummond, Filipe Rios Leite, Luciano Bernardes de Miranda, Denise Coutinho Drummond, Lucas Rios Lavorato, Victor Neiva Soares, Leôncio Lopes Neves, Clóvis Andrade Natali, Antônio José Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training |
title | Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training |
title_full | Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training |
title_fullStr | Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training |
title_full_unstemmed | Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training |
title_short | Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training |
title_sort | skeletal muscle dysfunctions in pulmonary arterial hypertension: effects of aerobic exercise training |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076612/ https://www.ncbi.nlm.nih.gov/pubmed/37035672 http://dx.doi.org/10.3389/fphys.2023.1148146 |
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