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A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers

Introduction: Several recent studies pointed out that chromodomain-helicase-DNA-binding protein 1-like (CHD1L) is a putative oncogene in many human tumors. However, up to date, there is no pan-cancer analysis performed to study the different aspects of this gene expression and behavior in tumor tiss...

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Autores principales: Soltan, Mohamed A., Eldeen, Muhammad Alaa, Eid, Refaat A., Alyamani, Najiah M., Alqahtani, Leena S., Albogami, Sarah, Jafri, Ibrahim, Park, Moon Nyeo, Alsharif, Ghadi, Fayad, Eman, Mohamed, Gamal, Osman, Rihab, Kim, Bonglee, Zaki, Mohamed Samir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076660/
https://www.ncbi.nlm.nih.gov/pubmed/37033447
http://dx.doi.org/10.3389/fmolb.2023.1017148
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author Soltan, Mohamed A.
Eldeen, Muhammad Alaa
Eid, Refaat A.
Alyamani, Najiah M.
Alqahtani, Leena S.
Albogami, Sarah
Jafri, Ibrahim
Park, Moon Nyeo
Alsharif, Ghadi
Fayad, Eman
Mohamed, Gamal
Osman, Rihab
Kim, Bonglee
Zaki, Mohamed Samir A.
author_facet Soltan, Mohamed A.
Eldeen, Muhammad Alaa
Eid, Refaat A.
Alyamani, Najiah M.
Alqahtani, Leena S.
Albogami, Sarah
Jafri, Ibrahim
Park, Moon Nyeo
Alsharif, Ghadi
Fayad, Eman
Mohamed, Gamal
Osman, Rihab
Kim, Bonglee
Zaki, Mohamed Samir A.
author_sort Soltan, Mohamed A.
collection PubMed
description Introduction: Several recent studies pointed out that chromodomain-helicase-DNA-binding protein 1-like (CHD1L) is a putative oncogene in many human tumors. However, up to date, there is no pan-cancer analysis performed to study the different aspects of this gene expression and behavior in tumor tissues. Methods: Here, we applied several bioinformatics tools to make a comprehensive analysis for CHD1L. Firstly we assessed the expression of CHD1L in several types of human tumors and tried to correlate that with the stage and grade of the analyzed tumors. Following that, we performed a survival analysis to study the correlation between CHD1L upregulation in tumors and the clinical outcome. Additionally, we investigated the mutation forms, the correlation with several immune cell infiltration, and the potential molecular mechanisms of CHD1L in the tumor tissue. Result and discussion: The results demonstrated that CHD1L is a highly expressed gene across several types of tumors and that was correlated with a poor prognosis for most cancer patients. Moreover, it was found that CHD1L affects the tumor immune microenvironment by influencing the infiltration level of several immune cells. Collectively, the current study provides a comprehensive overview of the oncogenic roles of CHD1L where our results nominate CHD1L as a potential prognostic biomarker and target for antitumor therapy development.
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spelling pubmed-100766602023-04-07 A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers Soltan, Mohamed A. Eldeen, Muhammad Alaa Eid, Refaat A. Alyamani, Najiah M. Alqahtani, Leena S. Albogami, Sarah Jafri, Ibrahim Park, Moon Nyeo Alsharif, Ghadi Fayad, Eman Mohamed, Gamal Osman, Rihab Kim, Bonglee Zaki, Mohamed Samir A. Front Mol Biosci Molecular Biosciences Introduction: Several recent studies pointed out that chromodomain-helicase-DNA-binding protein 1-like (CHD1L) is a putative oncogene in many human tumors. However, up to date, there is no pan-cancer analysis performed to study the different aspects of this gene expression and behavior in tumor tissues. Methods: Here, we applied several bioinformatics tools to make a comprehensive analysis for CHD1L. Firstly we assessed the expression of CHD1L in several types of human tumors and tried to correlate that with the stage and grade of the analyzed tumors. Following that, we performed a survival analysis to study the correlation between CHD1L upregulation in tumors and the clinical outcome. Additionally, we investigated the mutation forms, the correlation with several immune cell infiltration, and the potential molecular mechanisms of CHD1L in the tumor tissue. Result and discussion: The results demonstrated that CHD1L is a highly expressed gene across several types of tumors and that was correlated with a poor prognosis for most cancer patients. Moreover, it was found that CHD1L affects the tumor immune microenvironment by influencing the infiltration level of several immune cells. Collectively, the current study provides a comprehensive overview of the oncogenic roles of CHD1L where our results nominate CHD1L as a potential prognostic biomarker and target for antitumor therapy development. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076660/ /pubmed/37033447 http://dx.doi.org/10.3389/fmolb.2023.1017148 Text en Copyright © 2023 Soltan, Eldeen, Eid, Alyamani, Alqahtani, Albogami, Jafri, Park, Alsharif, Fayad, Mohamed, Osman, Kim and Zaki. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Soltan, Mohamed A.
Eldeen, Muhammad Alaa
Eid, Refaat A.
Alyamani, Najiah M.
Alqahtani, Leena S.
Albogami, Sarah
Jafri, Ibrahim
Park, Moon Nyeo
Alsharif, Ghadi
Fayad, Eman
Mohamed, Gamal
Osman, Rihab
Kim, Bonglee
Zaki, Mohamed Samir A.
A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers
title A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers
title_full A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers
title_fullStr A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers
title_full_unstemmed A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers
title_short A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancers
title_sort pan-cancer analysis reveals chd1l as a prognostic and immunological biomarker in several human cancers
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076660/
https://www.ncbi.nlm.nih.gov/pubmed/37033447
http://dx.doi.org/10.3389/fmolb.2023.1017148
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