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Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy

Terahertz (THz) technology has emerged as a promising tool for the qualitative and quantitative identification of markers containing major diseases, enabling early diagnosis and staged treatment of diseases. Nevertheless, the detection of water-containing biological samples is facing significant cha...

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Autores principales: Wang, Haiqing, Shi, Wei, Hou, Lei, Li, Chunhui, Zhang, Yusong, Yang, Lei, Cao, Juncheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076835/
https://www.ncbi.nlm.nih.gov/pubmed/37034259
http://dx.doi.org/10.3389/fbioe.2023.1170218
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author Wang, Haiqing
Shi, Wei
Hou, Lei
Li, Chunhui
Zhang, Yusong
Yang, Lei
Cao, Juncheng
author_facet Wang, Haiqing
Shi, Wei
Hou, Lei
Li, Chunhui
Zhang, Yusong
Yang, Lei
Cao, Juncheng
author_sort Wang, Haiqing
collection PubMed
description Terahertz (THz) technology has emerged as a promising tool for the qualitative and quantitative identification of markers containing major diseases, enabling early diagnosis and staged treatment of diseases. Nevertheless, the detection of water-containing biological samples is facing significant challenges due to limitations in high-power THz radiation sources and high-sensitivity detection devices. In this paper, we present a designed and constructed set of Terahertz-Attenuated Total Reflection (THz-ATR) spectrometer for high-sensitivity detection of liquid biological samples, which can dynamically maintain the signal-to-noise ratio (SNR) of THz detection signal of liquid biological samples at 40–60 dB. Our high-power THz-ATR spectroscopy can identify and quantitatively detect α-lactose aqueous solution with a minimum concentration of 0.292 mol/L. Moreover, we observed that the rate of change in the absorption peak position varied greatly between high and low concentration samples. Our high-power, high-sensitivity THz-ATR spectroscopy detection provides a rapid, accurate, and low-cost method for detecting disease markers such as blood and urine indicators. Additionally, this approach offers new perspectives for the refinement and in-depth detection of biomedical samples.
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spelling pubmed-100768352023-04-07 Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy Wang, Haiqing Shi, Wei Hou, Lei Li, Chunhui Zhang, Yusong Yang, Lei Cao, Juncheng Front Bioeng Biotechnol Bioengineering and Biotechnology Terahertz (THz) technology has emerged as a promising tool for the qualitative and quantitative identification of markers containing major diseases, enabling early diagnosis and staged treatment of diseases. Nevertheless, the detection of water-containing biological samples is facing significant challenges due to limitations in high-power THz radiation sources and high-sensitivity detection devices. In this paper, we present a designed and constructed set of Terahertz-Attenuated Total Reflection (THz-ATR) spectrometer for high-sensitivity detection of liquid biological samples, which can dynamically maintain the signal-to-noise ratio (SNR) of THz detection signal of liquid biological samples at 40–60 dB. Our high-power THz-ATR spectroscopy can identify and quantitatively detect α-lactose aqueous solution with a minimum concentration of 0.292 mol/L. Moreover, we observed that the rate of change in the absorption peak position varied greatly between high and low concentration samples. Our high-power, high-sensitivity THz-ATR spectroscopy detection provides a rapid, accurate, and low-cost method for detecting disease markers such as blood and urine indicators. Additionally, this approach offers new perspectives for the refinement and in-depth detection of biomedical samples. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076835/ /pubmed/37034259 http://dx.doi.org/10.3389/fbioe.2023.1170218 Text en Copyright © 2023 Wang, Shi, Hou, Li, Zhang, Yang and Cao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wang, Haiqing
Shi, Wei
Hou, Lei
Li, Chunhui
Zhang, Yusong
Yang, Lei
Cao, Juncheng
Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy
title Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy
title_full Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy
title_fullStr Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy
title_full_unstemmed Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy
title_short Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy
title_sort detection of the minimum concentrations of α-lactose solution using high-power thz-atr spectroscopy
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076835/
https://www.ncbi.nlm.nih.gov/pubmed/37034259
http://dx.doi.org/10.3389/fbioe.2023.1170218
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