Application of vertebral body compression osteotomy in pedicle subtraction osteotomy on ankylosing spondylitis kyphosis: Finite element analysis and retrospective study

BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease, with pathological characteristics of bone erosion, inflammation of attachment point, and bone ankylosis. Due to the ossified intervertebral disc and ligament, pedicle subtraction osteotomy (PSO) is one of the mainst...

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Autores principales: Yang, Canchun, Zeng, Ziliang, Yan, Haolin, Wu, Jionglin, Lv, Xin, Zhang, Di, Zhang, Zhilei, Jiang, Xu, Zhang, Chi, Fu, Guo, Peng, Xiaoshuai, Wang, Zheyu, Zhao, Qiancheng, Li, Wenpeng, Huang, Renyuan, Wang, Qiwei, Li, Bo, Hu, Xumin, Wang, Peng, Gao, Liangbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076869/
https://www.ncbi.nlm.nih.gov/pubmed/37033224
http://dx.doi.org/10.3389/fendo.2023.1131880
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author Yang, Canchun
Zeng, Ziliang
Yan, Haolin
Wu, Jionglin
Lv, Xin
Zhang, Di
Zhang, Zhilei
Jiang, Xu
Zhang, Chi
Fu, Guo
Peng, Xiaoshuai
Wang, Zheyu
Zhao, Qiancheng
Li, Wenpeng
Huang, Renyuan
Wang, Qiwei
Li, Bo
Hu, Xumin
Wang, Peng
Gao, Liangbin
author_facet Yang, Canchun
Zeng, Ziliang
Yan, Haolin
Wu, Jionglin
Lv, Xin
Zhang, Di
Zhang, Zhilei
Jiang, Xu
Zhang, Chi
Fu, Guo
Peng, Xiaoshuai
Wang, Zheyu
Zhao, Qiancheng
Li, Wenpeng
Huang, Renyuan
Wang, Qiwei
Li, Bo
Hu, Xumin
Wang, Peng
Gao, Liangbin
author_sort Yang, Canchun
collection PubMed
description BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease, with pathological characteristics of bone erosion, inflammation of attachment point, and bone ankylosis. Due to the ossified intervertebral disc and ligament, pedicle subtraction osteotomy (PSO) is one of the mainstream surgeries of AS-related thoracolumbar kyphosis, but the large amount of blood loss and high risk of instrumental instability limit its clinical application. The purpose of our study is to propose a new transpedicular vertebral body compression osteotomy (VBCO) in PSO to reduce blood loss and improve stability. METHODS: A retrospective analysis was performed on patients with AS-related thoracolumbar kyphosis who underwent one-level PSO in our hospital from February 2009 to May 2019. A total of 31 patients were included in this study; 6 received VBCO and 25 received eggshell vertebral body osteotomy. We collected demographic data containing gender and age at diagnosis. Surgical data contained operation time, estimated blood loss (EBL), and complications. Radiographic data contained pre-operative and follow-up sagittal parameters including chin brow-vertical angle (CBVA), global kyphosis (GK), thoracic kyphosis (TK), and lumbar lordosis (LL). A typical case with L2-PSO was used to establish a finite element model. The mechanical characteristics of the internal fixation device, vertebral body, and osteotomy plane of the two osteotomy models were analyzed under different working conditions. RESULTS: The VBCO could provide comparable restoring of CBVA, GK, TK, and LL in the eggshell osteotomy procedure (all p > 0.05). The VBCO significantly reduced EBL compared to those with eggshell osteotomy [800.0 ml (500.0–1,439.5 ml) vs. 1,455.5 ml (1,410.5–1,497.8 ml), p = 0.033]. Compared with the eggshell osteotomy, VBCO showed better mechanical property. For the intra-pedicular screw fixation, the VBCO group had a more average distributed and lower stress condition on both nails and connecting rod. VBCO had a flattened osteotomy plane than the pitted osteotomy plane of the eggshell group, showing a lower and more average distributed maximum stress and displacement of osteotomy plane. CONCLUSION: In our study, we introduced VBCO as an improved method in PSO, with advantages in reducing blood loss and providing greater stability. Further investigation should focus on clinical research and biomechanical analysis for the application of VBCO.
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spelling pubmed-100768692023-04-07 Application of vertebral body compression osteotomy in pedicle subtraction osteotomy on ankylosing spondylitis kyphosis: Finite element analysis and retrospective study Yang, Canchun Zeng, Ziliang Yan, Haolin Wu, Jionglin Lv, Xin Zhang, Di Zhang, Zhilei Jiang, Xu Zhang, Chi Fu, Guo Peng, Xiaoshuai Wang, Zheyu Zhao, Qiancheng Li, Wenpeng Huang, Renyuan Wang, Qiwei Li, Bo Hu, Xumin Wang, Peng Gao, Liangbin Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease, with pathological characteristics of bone erosion, inflammation of attachment point, and bone ankylosis. Due to the ossified intervertebral disc and ligament, pedicle subtraction osteotomy (PSO) is one of the mainstream surgeries of AS-related thoracolumbar kyphosis, but the large amount of blood loss and high risk of instrumental instability limit its clinical application. The purpose of our study is to propose a new transpedicular vertebral body compression osteotomy (VBCO) in PSO to reduce blood loss and improve stability. METHODS: A retrospective analysis was performed on patients with AS-related thoracolumbar kyphosis who underwent one-level PSO in our hospital from February 2009 to May 2019. A total of 31 patients were included in this study; 6 received VBCO and 25 received eggshell vertebral body osteotomy. We collected demographic data containing gender and age at diagnosis. Surgical data contained operation time, estimated blood loss (EBL), and complications. Radiographic data contained pre-operative and follow-up sagittal parameters including chin brow-vertical angle (CBVA), global kyphosis (GK), thoracic kyphosis (TK), and lumbar lordosis (LL). A typical case with L2-PSO was used to establish a finite element model. The mechanical characteristics of the internal fixation device, vertebral body, and osteotomy plane of the two osteotomy models were analyzed under different working conditions. RESULTS: The VBCO could provide comparable restoring of CBVA, GK, TK, and LL in the eggshell osteotomy procedure (all p > 0.05). The VBCO significantly reduced EBL compared to those with eggshell osteotomy [800.0 ml (500.0–1,439.5 ml) vs. 1,455.5 ml (1,410.5–1,497.8 ml), p = 0.033]. Compared with the eggshell osteotomy, VBCO showed better mechanical property. For the intra-pedicular screw fixation, the VBCO group had a more average distributed and lower stress condition on both nails and connecting rod. VBCO had a flattened osteotomy plane than the pitted osteotomy plane of the eggshell group, showing a lower and more average distributed maximum stress and displacement of osteotomy plane. CONCLUSION: In our study, we introduced VBCO as an improved method in PSO, with advantages in reducing blood loss and providing greater stability. Further investigation should focus on clinical research and biomechanical analysis for the application of VBCO. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076869/ /pubmed/37033224 http://dx.doi.org/10.3389/fendo.2023.1131880 Text en Copyright © 2023 Yang, Zeng, Yan, Wu, Lv, Zhang, Zhang, Jiang, Zhang, Fu, Peng, Wang, Zhao, Li, Huang, Wang, Li, Hu, Wang and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yang, Canchun
Zeng, Ziliang
Yan, Haolin
Wu, Jionglin
Lv, Xin
Zhang, Di
Zhang, Zhilei
Jiang, Xu
Zhang, Chi
Fu, Guo
Peng, Xiaoshuai
Wang, Zheyu
Zhao, Qiancheng
Li, Wenpeng
Huang, Renyuan
Wang, Qiwei
Li, Bo
Hu, Xumin
Wang, Peng
Gao, Liangbin
Application of vertebral body compression osteotomy in pedicle subtraction osteotomy on ankylosing spondylitis kyphosis: Finite element analysis and retrospective study
title Application of vertebral body compression osteotomy in pedicle subtraction osteotomy on ankylosing spondylitis kyphosis: Finite element analysis and retrospective study
title_full Application of vertebral body compression osteotomy in pedicle subtraction osteotomy on ankylosing spondylitis kyphosis: Finite element analysis and retrospective study
title_fullStr Application of vertebral body compression osteotomy in pedicle subtraction osteotomy on ankylosing spondylitis kyphosis: Finite element analysis and retrospective study
title_full_unstemmed Application of vertebral body compression osteotomy in pedicle subtraction osteotomy on ankylosing spondylitis kyphosis: Finite element analysis and retrospective study
title_short Application of vertebral body compression osteotomy in pedicle subtraction osteotomy on ankylosing spondylitis kyphosis: Finite element analysis and retrospective study
title_sort application of vertebral body compression osteotomy in pedicle subtraction osteotomy on ankylosing spondylitis kyphosis: finite element analysis and retrospective study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076869/
https://www.ncbi.nlm.nih.gov/pubmed/37033224
http://dx.doi.org/10.3389/fendo.2023.1131880
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