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On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders

Emerging brain technologies have significantly transformed human life in recent decades. For instance, the closed-loop brain-computer interface (BCI) is an advanced software-hardware system that interprets electrical signals from neurons, allowing communication with and control of the environment. T...

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Autores principales: Belkacem, Abdelkader Nasreddine, Jamil, Nuraini, Khalid, Sumayya, Alnajjar, Fady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076878/
https://www.ncbi.nlm.nih.gov/pubmed/37033911
http://dx.doi.org/10.3389/fnhum.2023.1085173
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author Belkacem, Abdelkader Nasreddine
Jamil, Nuraini
Khalid, Sumayya
Alnajjar, Fady
author_facet Belkacem, Abdelkader Nasreddine
Jamil, Nuraini
Khalid, Sumayya
Alnajjar, Fady
author_sort Belkacem, Abdelkader Nasreddine
collection PubMed
description Emerging brain technologies have significantly transformed human life in recent decades. For instance, the closed-loop brain-computer interface (BCI) is an advanced software-hardware system that interprets electrical signals from neurons, allowing communication with and control of the environment. The system then transmits these signals as controlled commands and provides feedback to the brain to execute specific tasks. This paper analyzes and presents the latest research on closed-loop BCI that utilizes electric/magnetic stimulation, optogenetic, and sonogenetic techniques. These techniques have demonstrated great potential in improving the quality of life for patients suffering from neurodegenerative or psychiatric diseases. We provide a comprehensive and systematic review of research on the modalities of closed-loop BCI in recent decades. To achieve this, the authors used a set of defined criteria to shortlist studies from well-known research databases into categories of brain stimulation techniques. These categories include deep brain stimulation, transcranial magnetic stimulation, transcranial direct-current stimulation, transcranial alternating-current stimulation, and optogenetics. These techniques have been useful in treating a wide range of disorders, such as Alzheimer's and Parkinson's disease, dementia, and depression. In total, 76 studies were shortlisted and analyzed to illustrate how closed-loop BCI can considerably improve, enhance, and restore specific brain functions. The analysis revealed that literature in the area has not adequately covered closed-loop BCI in the context of cognitive neural prosthetics and implanted neural devices. However, the authors demonstrate that the applications of closed-loop BCI are highly beneficial, and the technology is continually evolving to improve the lives of individuals with various ailments, including those with sensory-motor issues or cognitive deficiencies. By utilizing emerging techniques of stimulation, closed-loop BCI can safely improve patients' cognitive and affective skills, resulting in better healthcare outcomes.
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spelling pubmed-100768782023-04-07 On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders Belkacem, Abdelkader Nasreddine Jamil, Nuraini Khalid, Sumayya Alnajjar, Fady Front Hum Neurosci Human Neuroscience Emerging brain technologies have significantly transformed human life in recent decades. For instance, the closed-loop brain-computer interface (BCI) is an advanced software-hardware system that interprets electrical signals from neurons, allowing communication with and control of the environment. The system then transmits these signals as controlled commands and provides feedback to the brain to execute specific tasks. This paper analyzes and presents the latest research on closed-loop BCI that utilizes electric/magnetic stimulation, optogenetic, and sonogenetic techniques. These techniques have demonstrated great potential in improving the quality of life for patients suffering from neurodegenerative or psychiatric diseases. We provide a comprehensive and systematic review of research on the modalities of closed-loop BCI in recent decades. To achieve this, the authors used a set of defined criteria to shortlist studies from well-known research databases into categories of brain stimulation techniques. These categories include deep brain stimulation, transcranial magnetic stimulation, transcranial direct-current stimulation, transcranial alternating-current stimulation, and optogenetics. These techniques have been useful in treating a wide range of disorders, such as Alzheimer's and Parkinson's disease, dementia, and depression. In total, 76 studies were shortlisted and analyzed to illustrate how closed-loop BCI can considerably improve, enhance, and restore specific brain functions. The analysis revealed that literature in the area has not adequately covered closed-loop BCI in the context of cognitive neural prosthetics and implanted neural devices. However, the authors demonstrate that the applications of closed-loop BCI are highly beneficial, and the technology is continually evolving to improve the lives of individuals with various ailments, including those with sensory-motor issues or cognitive deficiencies. By utilizing emerging techniques of stimulation, closed-loop BCI can safely improve patients' cognitive and affective skills, resulting in better healthcare outcomes. Frontiers Media S.A. 2023-03-23 /pmc/articles/PMC10076878/ /pubmed/37033911 http://dx.doi.org/10.3389/fnhum.2023.1085173 Text en Copyright © 2023 Belkacem, Jamil, Khalid and Alnajjar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Belkacem, Abdelkader Nasreddine
Jamil, Nuraini
Khalid, Sumayya
Alnajjar, Fady
On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders
title On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders
title_full On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders
title_fullStr On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders
title_full_unstemmed On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders
title_short On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders
title_sort on closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076878/
https://www.ncbi.nlm.nih.gov/pubmed/37033911
http://dx.doi.org/10.3389/fnhum.2023.1085173
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