Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility

Based upon our demonstration that the smooth muscle cell–selective (SMC-selective) putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A, we examined Prdm6’s role in SMCs in vivo using cell type–specific knockout mouse models. Although SMC-specific depletion of P...

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Detalles Bibliográficos
Autores principales: Zou, Meng, Mangum, Kevin D., Magin, Justin C., Cao, Heidi H., Yarboro, Michael T., Shelton, Elaine L., Taylor, Joan M., Reese, Jeff, Furey, Terrence S., Mack, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077476/
https://www.ncbi.nlm.nih.gov/pubmed/36749647
http://dx.doi.org/10.1172/jci.insight.163454

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