Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation

Loss-of-function mutations in cerebral cavernous malformation (CCM) genes and gain-of-function mutation in the MAP3K3 gene encoding MEKK3 cause CCM. Deficiency of CCM proteins leads to the activation of MEKK3-KLF2/4 signaling, but it is not clear how this occurs. Here, we demonstrate that deletion o...

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Detalles Bibliográficos
Autores principales: Yang, Xi, Wu, Shi-Ting, Gao, Rui, Wang, Rui, Wang, Yixuan, Dong, Zhenkun, Wang, Lu, Qi, Chunxiao, Wang, Xiaohong, Schmitz, M. Lienhard, Liu, Renjing, Han, Zhiming, Zheng, Xiangjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077477/
https://www.ncbi.nlm.nih.gov/pubmed/36692953
http://dx.doi.org/10.1172/jci.insight.160372

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