CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling

Type II alveolar epithelial cell (AECII) redox imbalance contributes to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a deadly disease with limited treatment options. Here, we show that expression of membrane-bound cytochrome B5 reductase 3 (CYB5R3), an enzyme critical for maintaining cel...

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Detalles Bibliográficos
Autores principales: Bueno, Marta, Calyeca, Jazmin, Khaliullin, Timur, Miller, Megan P., Alvarez, Diana, Rosas, Lorena, Brands, Judith, Baker, Christian, Nasser, Amro, Shulkowski, Stephanie, Mathien, August, Uzoukwu, Nneoma, Sembrat, John, Mays, Brenton G., Fiedler, Kaitlin, Hahn, Scott A., Salvatore, Sonia R., Schopfer, Francisco J., Rojas, Mauricio, Sandner, Peter, Straub, Adam C., Mora, Ana L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077481/
https://www.ncbi.nlm.nih.gov/pubmed/36749633
http://dx.doi.org/10.1172/jci.insight.161487

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