Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx

The glomerular endothelial glycocalyx (GEnGlx) forms the first part of the glomerular filtration barrier. Previously, we showed that mineralocorticoid receptor (MR) activation caused GEnGlx damage and albuminuria. In this study, we investigated whether MR antagonism could limit albuminuria in diabet...

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Detalles Bibliográficos
Autores principales: Crompton, Michael, Ferguson, Joanne K., Ramnath, Raina D., Onions, Karen L., Ogier, Anna S., Gamez, Monica, Down, Colin J., Skinner, Laura, Wong, Kitty H., Dixon, Lauren K., Sutak, Judit, Harper, Steven J., Pontrelli, Paola, Gesualdo, Loreto, Heerspink, Hiddo L., Toto, Robert D., Welsh, Gavin I., Foster, Rebecca R., Satchell, Simon C., Butler, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077489/
https://www.ncbi.nlm.nih.gov/pubmed/36749631
http://dx.doi.org/10.1172/jci.insight.154164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077489/
https://www.ncbi.nlm.nih.gov/pubmed/36749631
http://dx.doi.org/10.1172/jci.insight.154164

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