ATM depletion induces proteasomal degradation of FANCD2 and sensitizes neuroblastoma cells to PARP inhibitors

BACKGROUND: Genomic alterations, including loss of function in chromosome band 11q22-23, are frequently observed in neuroblastoma, which is the most common extracranial childhood tumour. In neuroblastoma, ATM, a DNA damage response-associated gene located on 11q22-23, has been linked to tumorigenici...

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Detalles Bibliográficos
Autores principales: Parvin, Sultana, Akter, Jesmin, Takenobu, Hisanori, Katai, Yutaka, Satoh, Shunpei, Okada, Ryu, Haruta, Masayuki, Mukae, Kyosuke, Wada, Tomoko, Ohira, Miki, Ando, Kiyohiro, Kamijo, Takehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077671/
https://www.ncbi.nlm.nih.gov/pubmed/37020276
http://dx.doi.org/10.1186/s12885-023-10772-y

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