Optimal timing and sequence of combining stereotactic radiosurgery with immune checkpoint inhibitors in treating brain metastases: clinical evidence and mechanistic basis

Recent evidence has shown that immune checkpoint inhibitors (ICIs) are efficacious for treating brain metastases of various primary tumors. However, the immunosuppressive tumor microenvironment and the blood–brain barrier (BBB) or blood-tumor barrier (BTB) essentially restrict the efficacy of ICIs....

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Detalles Bibliográficos
Autores principales: Tian, Wentao, Chu, Xianjing, Tanzhu, Guilong, Zhou, Rongrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077682/
https://www.ncbi.nlm.nih.gov/pubmed/37020242
http://dx.doi.org/10.1186/s12967-023-04089-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077682/
https://www.ncbi.nlm.nih.gov/pubmed/37020242
http://dx.doi.org/10.1186/s12967-023-04089-4

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