Coexistence of Ectopic Tubal Pregnancy with Serous Tubal Intraepithelial Carcinoma: A Rare Case Report with Review of Literature

Serous tubal intraepithelial carcinoma is a precursor lesion for high-grade pelvic serous carcinoma. The incidence is 0.6%–6% in tubectomy specimens of women who are BRCA-1,2 positive or have a strong family history of breast or ovarian cancer. STIC in women who do not have BRCA-1,2 mutations or con...

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Autores principales: Chandanwale, Shirish Sahebrao, Lad, Yesha Parimalbhai, Bardapurkar, Padmakar Rajabhau, Buch, Archana Chirag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077741/
https://www.ncbi.nlm.nih.gov/pubmed/37033139
http://dx.doi.org/10.4103/jhrs.jhrs_134_22
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author Chandanwale, Shirish Sahebrao
Lad, Yesha Parimalbhai
Bardapurkar, Padmakar Rajabhau
Buch, Archana Chirag
author_facet Chandanwale, Shirish Sahebrao
Lad, Yesha Parimalbhai
Bardapurkar, Padmakar Rajabhau
Buch, Archana Chirag
author_sort Chandanwale, Shirish Sahebrao
collection PubMed
description Serous tubal intraepithelial carcinoma is a precursor lesion for high-grade pelvic serous carcinoma. The incidence is 0.6%–6% in tubectomy specimens of women who are BRCA-1,2 positive or have a strong family history of breast or ovarian cancer. STIC in women who do not have BRCA-1,2 mutations or concomitant high-grade serous carcinoma is exceedingly rare. Ectopic tubal gestation coexisting with serous tubal intraepithelial carcinoma is very rarely reported. These lesions pose considerable difficulty in the diagnosis. A combination of histology and immunohistochemical expression p53 and ki67 substantially improves the reproducibility of the diagnosis. Diagnosing these lesions will help identify potential at risk patients and their families for carcinoma. Adequate prolonged follow-up for incidental serous tubal intraepithelial carcinoma is the mainstay. We report one such case of a 31-year-old female who was operated for the right tubal gestation and found to have serous tubal intraepithelial carcinoma.
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spelling pubmed-100777412023-04-07 Coexistence of Ectopic Tubal Pregnancy with Serous Tubal Intraepithelial Carcinoma: A Rare Case Report with Review of Literature Chandanwale, Shirish Sahebrao Lad, Yesha Parimalbhai Bardapurkar, Padmakar Rajabhau Buch, Archana Chirag J Hum Reprod Sci Case Report Serous tubal intraepithelial carcinoma is a precursor lesion for high-grade pelvic serous carcinoma. The incidence is 0.6%–6% in tubectomy specimens of women who are BRCA-1,2 positive or have a strong family history of breast or ovarian cancer. STIC in women who do not have BRCA-1,2 mutations or concomitant high-grade serous carcinoma is exceedingly rare. Ectopic tubal gestation coexisting with serous tubal intraepithelial carcinoma is very rarely reported. These lesions pose considerable difficulty in the diagnosis. A combination of histology and immunohistochemical expression p53 and ki67 substantially improves the reproducibility of the diagnosis. Diagnosing these lesions will help identify potential at risk patients and their families for carcinoma. Adequate prolonged follow-up for incidental serous tubal intraepithelial carcinoma is the mainstay. We report one such case of a 31-year-old female who was operated for the right tubal gestation and found to have serous tubal intraepithelial carcinoma. Wolters Kluwer - Medknow 2022 2022-12-13 /pmc/articles/PMC10077741/ /pubmed/37033139 http://dx.doi.org/10.4103/jhrs.jhrs_134_22 Text en Copyright: © 2022 Journal of Human Reproductive Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Chandanwale, Shirish Sahebrao
Lad, Yesha Parimalbhai
Bardapurkar, Padmakar Rajabhau
Buch, Archana Chirag
Coexistence of Ectopic Tubal Pregnancy with Serous Tubal Intraepithelial Carcinoma: A Rare Case Report with Review of Literature
title Coexistence of Ectopic Tubal Pregnancy with Serous Tubal Intraepithelial Carcinoma: A Rare Case Report with Review of Literature
title_full Coexistence of Ectopic Tubal Pregnancy with Serous Tubal Intraepithelial Carcinoma: A Rare Case Report with Review of Literature
title_fullStr Coexistence of Ectopic Tubal Pregnancy with Serous Tubal Intraepithelial Carcinoma: A Rare Case Report with Review of Literature
title_full_unstemmed Coexistence of Ectopic Tubal Pregnancy with Serous Tubal Intraepithelial Carcinoma: A Rare Case Report with Review of Literature
title_short Coexistence of Ectopic Tubal Pregnancy with Serous Tubal Intraepithelial Carcinoma: A Rare Case Report with Review of Literature
title_sort coexistence of ectopic tubal pregnancy with serous tubal intraepithelial carcinoma: a rare case report with review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077741/
https://www.ncbi.nlm.nih.gov/pubmed/37033139
http://dx.doi.org/10.4103/jhrs.jhrs_134_22
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