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Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)

Extension of the COVERALL (COrona VaccinE tRiAL pLatform) randomized trial showed noninferiority in antibody response of the third dose of Moderna mRNA-1273 vaccine (95.3% [95% confidence interval {CI}, 91.9%–98.7%]) compared to Pfizer-BioNTech BNT162b2 vaccine (98.1% [95% CI, 95.9%–100.0%]) in indi...

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Autores principales: Griessbach, Alexandra, Chammartin, Frédérique, Abela, Irene A, Amico, Patrizia, Stoeckle, Marcel P, Eichenberger, Anna L, Hasse, Barbara, Braun, Dominique L, Schuurmans, Macé M, Müller, Thomas F, Tamm, Michael, Audigé, Annette, Mueller, Nicolas J, Rauch, Andri, Günthard, Huldrych F, Koller, Michael T, Trkola, Alexandra, Epp, Selina, Amstutz, Alain, Schönenberger, Christof M, Taji Heravi, Ala, Kusejko, Katharina, Bucher, Heiner C, Briel, Matthias, Speich, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077822/
https://www.ncbi.nlm.nih.gov/pubmed/37035486
http://dx.doi.org/10.1093/ofid/ofad150
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author Griessbach, Alexandra
Chammartin, Frédérique
Abela, Irene A
Amico, Patrizia
Stoeckle, Marcel P
Eichenberger, Anna L
Hasse, Barbara
Braun, Dominique L
Schuurmans, Macé M
Müller, Thomas F
Tamm, Michael
Audigé, Annette
Mueller, Nicolas J
Rauch, Andri
Günthard, Huldrych F
Koller, Michael T
Trkola, Alexandra
Epp, Selina
Amstutz, Alain
Schönenberger, Christof M
Taji Heravi, Ala
Kusejko, Katharina
Bucher, Heiner C
Briel, Matthias
Speich, Benjamin
author_facet Griessbach, Alexandra
Chammartin, Frédérique
Abela, Irene A
Amico, Patrizia
Stoeckle, Marcel P
Eichenberger, Anna L
Hasse, Barbara
Braun, Dominique L
Schuurmans, Macé M
Müller, Thomas F
Tamm, Michael
Audigé, Annette
Mueller, Nicolas J
Rauch, Andri
Günthard, Huldrych F
Koller, Michael T
Trkola, Alexandra
Epp, Selina
Amstutz, Alain
Schönenberger, Christof M
Taji Heravi, Ala
Kusejko, Katharina
Bucher, Heiner C
Briel, Matthias
Speich, Benjamin
author_sort Griessbach, Alexandra
collection PubMed
description Extension of the COVERALL (COrona VaccinE tRiAL pLatform) randomized trial showed noninferiority in antibody response of the third dose of Moderna mRNA-1273 vaccine (95.3% [95% confidence interval {CI}, 91.9%–98.7%]) compared to Pfizer-BioNTech BNT162b2 vaccine (98.1% [95% CI, 95.9%–100.0%]) in individuals with different levels of immunosuppression (difference, −2.8% [95% CI, −6.8% to 1.3%]).
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spelling pubmed-100778222023-04-07 Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2) Griessbach, Alexandra Chammartin, Frédérique Abela, Irene A Amico, Patrizia Stoeckle, Marcel P Eichenberger, Anna L Hasse, Barbara Braun, Dominique L Schuurmans, Macé M Müller, Thomas F Tamm, Michael Audigé, Annette Mueller, Nicolas J Rauch, Andri Günthard, Huldrych F Koller, Michael T Trkola, Alexandra Epp, Selina Amstutz, Alain Schönenberger, Christof M Taji Heravi, Ala Kusejko, Katharina Bucher, Heiner C Briel, Matthias Speich, Benjamin Open Forum Infect Dis Brief Report Extension of the COVERALL (COrona VaccinE tRiAL pLatform) randomized trial showed noninferiority in antibody response of the third dose of Moderna mRNA-1273 vaccine (95.3% [95% confidence interval {CI}, 91.9%–98.7%]) compared to Pfizer-BioNTech BNT162b2 vaccine (98.1% [95% CI, 95.9%–100.0%]) in individuals with different levels of immunosuppression (difference, −2.8% [95% CI, −6.8% to 1.3%]). Oxford University Press 2023-03-30 /pmc/articles/PMC10077822/ /pubmed/37035486 http://dx.doi.org/10.1093/ofid/ofad150 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Griessbach, Alexandra
Chammartin, Frédérique
Abela, Irene A
Amico, Patrizia
Stoeckle, Marcel P
Eichenberger, Anna L
Hasse, Barbara
Braun, Dominique L
Schuurmans, Macé M
Müller, Thomas F
Tamm, Michael
Audigé, Annette
Mueller, Nicolas J
Rauch, Andri
Günthard, Huldrych F
Koller, Michael T
Trkola, Alexandra
Epp, Selina
Amstutz, Alain
Schönenberger, Christof M
Taji Heravi, Ala
Kusejko, Katharina
Bucher, Heiner C
Briel, Matthias
Speich, Benjamin
Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)
title Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)
title_full Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)
title_fullStr Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)
title_full_unstemmed Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)
title_short Antibody Response After Third Vaccination With mRNA-1273 or BNT162b2: Extension of a Randomized Controlled SARS-CoV-2 Noninferiority Vaccine Trial in Patients With Different Levels of Immunosuppression (COVERALL-2)
title_sort antibody response after third vaccination with mrna-1273 or bnt162b2: extension of a randomized controlled sars-cov-2 noninferiority vaccine trial in patients with different levels of immunosuppression (coverall-2)
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077822/
https://www.ncbi.nlm.nih.gov/pubmed/37035486
http://dx.doi.org/10.1093/ofid/ofad150
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