Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1(I249/M280)-expressing retina

Diabetic retinopathy, a microvascular disease characterized by irreparable vascular damage, neurodegeneration and neuroinflammation, is a leading complication of diabetes mellitus. There is no cure for DR, and medical interventions marginally slow the progression of disease. Microglia-mediated infla...

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Detalles Bibliográficos
Autores principales: Church, Kaira A., Rodriguez, Derek, Mendiola, Andrew S., Vanegas, Difernando, Gutierrez, Irene L., Tamayo, Ian, Amadu, Abdul, Velazquez, Priscila, Cardona, Sandra M., Gyoneva, Stefka, Cotleur, Anne C., Ransohoff, Richard M., Kaur, Tejbeer, Cardona, Astrid E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077890/
https://www.ncbi.nlm.nih.gov/pubmed/37033925
http://dx.doi.org/10.3389/fimmu.2023.1130735

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