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Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy to affect women of reproductive‐age world‐wide. Hyperandrogenism is both a hallmark feature of PCOS, and is hypothesised to be an underlying mechanism driving the development of the condition in utero. With circulating hormones known...

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Autores principales: Khant Aung, Zin, Masih, Renee R., Desroziers, Elodie, Campbell, Rebecca E., Brown, Rosemary S. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077988/
https://www.ncbi.nlm.nih.gov/pubmed/36416198
http://dx.doi.org/10.1111/jne.13206
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author Khant Aung, Zin
Masih, Renee R.
Desroziers, Elodie
Campbell, Rebecca E.
Brown, Rosemary S. E.
author_facet Khant Aung, Zin
Masih, Renee R.
Desroziers, Elodie
Campbell, Rebecca E.
Brown, Rosemary S. E.
author_sort Khant Aung, Zin
collection PubMed
description Polycystic ovary syndrome (PCOS) is the most common endocrinopathy to affect women of reproductive‐age world‐wide. Hyperandrogenism is both a hallmark feature of PCOS, and is hypothesised to be an underlying mechanism driving the development of the condition in utero. With circulating hormones known to profoundly influence maternal responses in females, we aimed to determine whether maternal behaviour is altered in a well‐described prenatally androgenised (PNA) mouse model of PCOS. Mouse dams were administered with dihydrotestosterone or vehicle on days 16, 17 and 18 of pregnancy. Maternal responses were assessed in both the dihydrotestosterone‐injected dams following parturition and in their adult female PNA offspring. Exposure of dams to excess androgens during late pregnancy had no detrimental effects on pregnancy outcomes, including gestation length, pup survival and gestational weight gain, or on subsequent maternal behaviour following parturition. By contrast, PNA virgin females, modelling PCOS, exhibited enhanced maternal behaviour when tested in an anxiogenic novel cage environment, with females rapidly retrieving pups and nesting with them. In comparison, most control virgin females failed to complete this retrieval task in the anxiogenic environment. Assessment of progesterone receptor and oestrogen receptor α immunoreactivity in the brains of virgin PNA and control females revealed increased numbers of oestrogen receptor α positive cells in the brains of PNA females in regions well known to be important for maternal behaviour. This suggests that increased oestrogenic signalling in the neural circuit that underlies maternal behaviour may be a possible mechanism by which maternal behaviour is enhanced in PNA female mice.
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spelling pubmed-100779882023-04-07 Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome Khant Aung, Zin Masih, Renee R. Desroziers, Elodie Campbell, Rebecca E. Brown, Rosemary S. E. J Neuroendocrinol Fundamental and Mechanistic Neuroendocrinology Polycystic ovary syndrome (PCOS) is the most common endocrinopathy to affect women of reproductive‐age world‐wide. Hyperandrogenism is both a hallmark feature of PCOS, and is hypothesised to be an underlying mechanism driving the development of the condition in utero. With circulating hormones known to profoundly influence maternal responses in females, we aimed to determine whether maternal behaviour is altered in a well‐described prenatally androgenised (PNA) mouse model of PCOS. Mouse dams were administered with dihydrotestosterone or vehicle on days 16, 17 and 18 of pregnancy. Maternal responses were assessed in both the dihydrotestosterone‐injected dams following parturition and in their adult female PNA offspring. Exposure of dams to excess androgens during late pregnancy had no detrimental effects on pregnancy outcomes, including gestation length, pup survival and gestational weight gain, or on subsequent maternal behaviour following parturition. By contrast, PNA virgin females, modelling PCOS, exhibited enhanced maternal behaviour when tested in an anxiogenic novel cage environment, with females rapidly retrieving pups and nesting with them. In comparison, most control virgin females failed to complete this retrieval task in the anxiogenic environment. Assessment of progesterone receptor and oestrogen receptor α immunoreactivity in the brains of virgin PNA and control females revealed increased numbers of oestrogen receptor α positive cells in the brains of PNA females in regions well known to be important for maternal behaviour. This suggests that increased oestrogenic signalling in the neural circuit that underlies maternal behaviour may be a possible mechanism by which maternal behaviour is enhanced in PNA female mice. John Wiley and Sons Inc. 2022-11-23 2022-12 /pmc/articles/PMC10077988/ /pubmed/36416198 http://dx.doi.org/10.1111/jne.13206 Text en © 2022 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Fundamental and Mechanistic Neuroendocrinology
Khant Aung, Zin
Masih, Renee R.
Desroziers, Elodie
Campbell, Rebecca E.
Brown, Rosemary S. E.
Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome
title Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome
title_full Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome
title_fullStr Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome
title_full_unstemmed Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome
title_short Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome
title_sort enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome
topic Fundamental and Mechanistic Neuroendocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077988/
https://www.ncbi.nlm.nih.gov/pubmed/36416198
http://dx.doi.org/10.1111/jne.13206
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