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Indirect effects of cytomegalovirus infection: Implications for vaccine development
Development of a cytomegalovirus (CMV) vaccine is a high priority due to its significant global impact—contributing to mortality in immunosuppressed individuals, neurodevelopmental delay in infected neonates and non‐genetic sensorineural hearing loss. The impact of CMV on the general population has...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078107/ https://www.ncbi.nlm.nih.gov/pubmed/36378563 http://dx.doi.org/10.1002/rmv.2405 |
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author | Moseley, Philip Klenerman, Paul Kadambari, Seilesh |
author_facet | Moseley, Philip Klenerman, Paul Kadambari, Seilesh |
author_sort | Moseley, Philip |
collection | PubMed |
description | Development of a cytomegalovirus (CMV) vaccine is a high priority due to its significant global impact—contributing to mortality in immunosuppressed individuals, neurodevelopmental delay in infected neonates and non‐genetic sensorineural hearing loss. The impact of CMV on the general population has been less well studied; however, a wide range of evidence indicates that CMV may increase the risk of atherosclerosis, cancer, immunosenescence, and progression of tuberculosis (TB) and human immunodeficiency virus. Due to the high seroprevalence of CMV worldwide, any modulation of risk by CMV is likely to have a significant impact on the epidemiology of these diseases. This review will evaluate how CMV may cause morbidity and mortality outside of the neonatal and immunosuppressed populations and consider the potential impact of a CMV vaccine on these outcomes. |
format | Online Article Text |
id | pubmed-10078107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100781072023-04-07 Indirect effects of cytomegalovirus infection: Implications for vaccine development Moseley, Philip Klenerman, Paul Kadambari, Seilesh Rev Med Virol Reviews Development of a cytomegalovirus (CMV) vaccine is a high priority due to its significant global impact—contributing to mortality in immunosuppressed individuals, neurodevelopmental delay in infected neonates and non‐genetic sensorineural hearing loss. The impact of CMV on the general population has been less well studied; however, a wide range of evidence indicates that CMV may increase the risk of atherosclerosis, cancer, immunosenescence, and progression of tuberculosis (TB) and human immunodeficiency virus. Due to the high seroprevalence of CMV worldwide, any modulation of risk by CMV is likely to have a significant impact on the epidemiology of these diseases. This review will evaluate how CMV may cause morbidity and mortality outside of the neonatal and immunosuppressed populations and consider the potential impact of a CMV vaccine on these outcomes. John Wiley and Sons Inc. 2022-11-15 2023-01 /pmc/articles/PMC10078107/ /pubmed/36378563 http://dx.doi.org/10.1002/rmv.2405 Text en © 2022 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Moseley, Philip Klenerman, Paul Kadambari, Seilesh Indirect effects of cytomegalovirus infection: Implications for vaccine development |
title | Indirect effects of cytomegalovirus infection: Implications for vaccine development |
title_full | Indirect effects of cytomegalovirus infection: Implications for vaccine development |
title_fullStr | Indirect effects of cytomegalovirus infection: Implications for vaccine development |
title_full_unstemmed | Indirect effects of cytomegalovirus infection: Implications for vaccine development |
title_short | Indirect effects of cytomegalovirus infection: Implications for vaccine development |
title_sort | indirect effects of cytomegalovirus infection: implications for vaccine development |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078107/ https://www.ncbi.nlm.nih.gov/pubmed/36378563 http://dx.doi.org/10.1002/rmv.2405 |
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