Tissue-resident memory T cells in immune-related adverse events: friend or foe?

Many cancer patients experience toxicity during checkpoint blockade immunotherapy, which often leads to treatment discontinuation. To this end, understanding the mechanisms mediating immune-related adverse events (irAE) should ultimately enable improvement in clinical outcomes. Recent work has revea...

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Detalles Bibliográficos
Autores principales: Reschke, Robin, Gajewski, Thomas F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078118/
https://www.ncbi.nlm.nih.gov/pubmed/37035636
http://dx.doi.org/10.1080/2162402X.2023.2197358
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author Reschke, Robin
Gajewski, Thomas F
author_facet Reschke, Robin
Gajewski, Thomas F
author_sort Reschke, Robin
collection PubMed
description Many cancer patients experience toxicity during checkpoint blockade immunotherapy, which often leads to treatment discontinuation. To this end, understanding the mechanisms mediating immune-related adverse events (irAE) should ultimately enable improvement in clinical outcomes. Recent work has revealed that tissue-resident memory T (T(RM)) cells are locally expanded in irAE-dermatitis and -colitis.
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spelling pubmed-100781182023-04-07 Tissue-resident memory T cells in immune-related adverse events: friend or foe? Reschke, Robin Gajewski, Thomas F Oncoimmunology Author’s View Many cancer patients experience toxicity during checkpoint blockade immunotherapy, which often leads to treatment discontinuation. To this end, understanding the mechanisms mediating immune-related adverse events (irAE) should ultimately enable improvement in clinical outcomes. Recent work has revealed that tissue-resident memory T (T(RM)) cells are locally expanded in irAE-dermatitis and -colitis. Taylor & Francis 2023-04-04 /pmc/articles/PMC10078118/ /pubmed/37035636 http://dx.doi.org/10.1080/2162402X.2023.2197358 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Author’s View
Reschke, Robin
Gajewski, Thomas F
Tissue-resident memory T cells in immune-related adverse events: friend or foe?
title Tissue-resident memory T cells in immune-related adverse events: friend or foe?
title_full Tissue-resident memory T cells in immune-related adverse events: friend or foe?
title_fullStr Tissue-resident memory T cells in immune-related adverse events: friend or foe?
title_full_unstemmed Tissue-resident memory T cells in immune-related adverse events: friend or foe?
title_short Tissue-resident memory T cells in immune-related adverse events: friend or foe?
title_sort tissue-resident memory t cells in immune-related adverse events: friend or foe?
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078118/
https://www.ncbi.nlm.nih.gov/pubmed/37035636
http://dx.doi.org/10.1080/2162402X.2023.2197358
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