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Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study

Given the potential for nosocomial outbreaks, we must understand factors associated with negative vaccine attitudes amongst healthcare professionals (HCPs) before the rollout of a newly developed vaccine in a pandemic setting. The aim of this prospective cohort study was to study the impact of preex...

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Autores principales: Collett, George, Godec, Thomas, Gupta, Ajay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078128/
https://www.ncbi.nlm.nih.gov/pubmed/36977613
http://dx.doi.org/10.1080/21645515.2023.2188823
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author Collett, George
Godec, Thomas
Gupta, Ajay K.
author_facet Collett, George
Godec, Thomas
Gupta, Ajay K.
author_sort Collett, George
collection PubMed
description Given the potential for nosocomial outbreaks, we must understand factors associated with negative vaccine attitudes amongst healthcare professionals (HCPs) before the rollout of a newly developed vaccine in a pandemic setting. The aim of this prospective cohort study was to study the impact of preexisting and prevailing mental health on United Kingdom HCPs’ attitudes towards a newly developed COVID-19 vaccine. Two online surveys were distributed: first during vaccine development (July–September, 2020) and second during nationwide vaccine rollout (December 2020–March 2021). Mental health (PHQ-9 for depression; GAD-7 for anxiety) was assessed in both surveys. Negative attitude regarding vaccine safety and vaccine effectiveness was assessed at vaccine rollout. A series of logistic regression models were developed relating mental health (preexisting during vaccine development, ongoing and new-onset during rollout, and changes in symptom severity) to negative vaccine attitudes. In 634 HCPs, the presence of depression and/or anxiety during vaccine development was associated with elevated negative attitude towards vaccine safety (adj. OR 1.74 [95% CI 1.10–2.75], p = .02), but not vaccine effectiveness (1.13 [0.77–1.66], p = .53) at rollout. This was independent of other characteristics: age, ethnicity, professional role, and history of contracting COVID-19. Ongoing depression and/or anxiety (1.72 [1.10–2.69], p = .02) was associated with elevated negative attitude regarding vaccine effectiveness, but not vaccine safety. Worsened combined symptom scores over time were associated with elevated negative vaccine effectiveness attitudes (1.03 [1.00–1.05], p < .05), but not vaccine safety. Overall, adverse mental health can impact on HCPs’ attitudes towards a newly developed vaccine. Further work is required to understand how this translates to vaccine uptake.
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spelling pubmed-100781282023-04-07 Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study Collett, George Godec, Thomas Gupta, Ajay K. Hum Vaccin Immunother Coronavirus Given the potential for nosocomial outbreaks, we must understand factors associated with negative vaccine attitudes amongst healthcare professionals (HCPs) before the rollout of a newly developed vaccine in a pandemic setting. The aim of this prospective cohort study was to study the impact of preexisting and prevailing mental health on United Kingdom HCPs’ attitudes towards a newly developed COVID-19 vaccine. Two online surveys were distributed: first during vaccine development (July–September, 2020) and second during nationwide vaccine rollout (December 2020–March 2021). Mental health (PHQ-9 for depression; GAD-7 for anxiety) was assessed in both surveys. Negative attitude regarding vaccine safety and vaccine effectiveness was assessed at vaccine rollout. A series of logistic regression models were developed relating mental health (preexisting during vaccine development, ongoing and new-onset during rollout, and changes in symptom severity) to negative vaccine attitudes. In 634 HCPs, the presence of depression and/or anxiety during vaccine development was associated with elevated negative attitude towards vaccine safety (adj. OR 1.74 [95% CI 1.10–2.75], p = .02), but not vaccine effectiveness (1.13 [0.77–1.66], p = .53) at rollout. This was independent of other characteristics: age, ethnicity, professional role, and history of contracting COVID-19. Ongoing depression and/or anxiety (1.72 [1.10–2.69], p = .02) was associated with elevated negative attitude regarding vaccine effectiveness, but not vaccine safety. Worsened combined symptom scores over time were associated with elevated negative vaccine effectiveness attitudes (1.03 [1.00–1.05], p < .05), but not vaccine safety. Overall, adverse mental health can impact on HCPs’ attitudes towards a newly developed vaccine. Further work is required to understand how this translates to vaccine uptake. Taylor & Francis 2023-03-28 /pmc/articles/PMC10078128/ /pubmed/36977613 http://dx.doi.org/10.1080/21645515.2023.2188823 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Coronavirus
Collett, George
Godec, Thomas
Gupta, Ajay K.
Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study
title Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study
title_full Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study
title_fullStr Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study
title_full_unstemmed Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study
title_short Factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst UK healthcare professionals prior to and at the time of COVID-19 vaccine rollout: Insights from the CoPE-HCP cohort study
title_sort factors influencing attitudes toward vaccine safety and vaccine effectiveness amongst uk healthcare professionals prior to and at the time of covid-19 vaccine rollout: insights from the cope-hcp cohort study
topic Coronavirus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078128/
https://www.ncbi.nlm.nih.gov/pubmed/36977613
http://dx.doi.org/10.1080/21645515.2023.2188823
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