Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis

Severe acne is a chronic inflammatory skin condition that is affected by both genetic and environmental factors. DNA methylation is associated with a variety of inflammatory skin diseases, but its role in severe acne is unclear. In this study, we conducted a two-stage epigenome correlation study usi...

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Autores principales: Wang, Huai, Dang, Tianyuan, Feng, Jiaqi, Wu, Wenjuan, He, Li, Yang, Jiankang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078136/
https://www.ncbi.nlm.nih.gov/pubmed/37018476
http://dx.doi.org/10.1080/15592294.2023.2199373
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author Wang, Huai
Dang, Tianyuan
Feng, Jiaqi
Wu, Wenjuan
He, Li
Yang, Jiankang
author_facet Wang, Huai
Dang, Tianyuan
Feng, Jiaqi
Wu, Wenjuan
He, Li
Yang, Jiankang
author_sort Wang, Huai
collection PubMed
description Severe acne is a chronic inflammatory skin condition that is affected by both genetic and environmental factors. DNA methylation is associated with a variety of inflammatory skin diseases, but its role in severe acne is unclear. In this study, we conducted a two-stage epigenome correlation study using 88 blood samples to identify disease-related differential methylation sites. We found close associations between the DNA methylation at 23 differentially methylated sites (DMSs) and severe acne, including PDGFD, ARHGEF10, etc. Further analysis revealed that differentially methylated genes (PARP8 and MAPKAPK2) were also expressed differently between severe acne and health control groups. These findings lead us to speculation that epigenetic mechanisms may play an important role in the pathogenesis of severe acne.
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spelling pubmed-100781362023-04-07 Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis Wang, Huai Dang, Tianyuan Feng, Jiaqi Wu, Wenjuan He, Li Yang, Jiankang Epigenetics Research Paper Severe acne is a chronic inflammatory skin condition that is affected by both genetic and environmental factors. DNA methylation is associated with a variety of inflammatory skin diseases, but its role in severe acne is unclear. In this study, we conducted a two-stage epigenome correlation study using 88 blood samples to identify disease-related differential methylation sites. We found close associations between the DNA methylation at 23 differentially methylated sites (DMSs) and severe acne, including PDGFD, ARHGEF10, etc. Further analysis revealed that differentially methylated genes (PARP8 and MAPKAPK2) were also expressed differently between severe acne and health control groups. These findings lead us to speculation that epigenetic mechanisms may play an important role in the pathogenesis of severe acne. Taylor & Francis 2023-04-05 /pmc/articles/PMC10078136/ /pubmed/37018476 http://dx.doi.org/10.1080/15592294.2023.2199373 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Research Paper
Wang, Huai
Dang, Tianyuan
Feng, Jiaqi
Wu, Wenjuan
He, Li
Yang, Jiankang
Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis
title Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis
title_full Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis
title_fullStr Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis
title_full_unstemmed Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis
title_short Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis
title_sort identification of differentially methylated genes for severe acne by genome-wide dna methylation and gene expression analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078136/
https://www.ncbi.nlm.nih.gov/pubmed/37018476
http://dx.doi.org/10.1080/15592294.2023.2199373
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