Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cells

Some metallo-supramolecular helical assemblies with size, shape, charge and amphipathic architectures similar to short cationic α-helical peptides have been shown to target and stabilise DNA G-quadruplexes (G4s) in vitro and downregulate the expression of G4-regulated genes in human cells. To expand...

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Detalles Bibliográficos
Autores principales: Malina, Jaroslav, Kostrhunova, Hana, Song, Hualong, Scott, Peter, Brabec, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078150/
https://www.ncbi.nlm.nih.gov/pubmed/37019444
http://dx.doi.org/10.1080/14756366.2023.2198678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078150/
https://www.ncbi.nlm.nih.gov/pubmed/37019444
http://dx.doi.org/10.1080/14756366.2023.2198678

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