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Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors
BACKGROUND: The impact of donor age on the immune reconstitution of patients with hematological malignancies who underwent hematopoietic cell transplantation (HCT) is unclear. METHOD: We retrospectively compared the outcomes of 381 patients who underwent allogeneic peripheral blood stem cell transpl...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078254/ https://www.ncbi.nlm.nih.gov/pubmed/36318732 http://dx.doi.org/10.1111/ctr.14844 |
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author | Jiang, Peiyao Cai, Yu Zhou, Xiao Yang, Jun Tong, Yin Huang, Chongmei Qiu, Huiying Zhou, Kun Xu, Xiaowei Zhang, Ying Niu, Jiahua Shen, Chang Xia, Xinxin Wei, Yu Song, Xianmin Wan, Liping |
author_facet | Jiang, Peiyao Cai, Yu Zhou, Xiao Yang, Jun Tong, Yin Huang, Chongmei Qiu, Huiying Zhou, Kun Xu, Xiaowei Zhang, Ying Niu, Jiahua Shen, Chang Xia, Xinxin Wei, Yu Song, Xianmin Wan, Liping |
author_sort | Jiang, Peiyao |
collection | PubMed |
description | BACKGROUND: The impact of donor age on the immune reconstitution of patients with hematological malignancies who underwent hematopoietic cell transplantation (HCT) is unclear. METHOD: We retrospectively compared the outcomes of 381 patients who underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from 308 donors under 50 years of age and 73 donors over 50 years of age. IVIG was regularly supplemented for patients in the first 3 months post‐HCT. RESULTS: The counts of CD8+CD45RA+ naïve T cells were significantly lower in patients of the older donor group than in the younger donor group in the first year after PBSCT (190.6 cells/μl vs. 239.6 cells/μl, p = .018). Patients in the older donor group had significantly fewer CD19+ B cells on day +270 (123.4 cells/μl vs. 183.5 cells/μl, p = .021) and day +365 (169 cells/μl vs. 271.1 cells/μl, p = .01) after PBSCT. Serum IgA (.76 g/L vs. .97 g/L, p < .001) and IgM levels (.75 g/L vs. 1.04 g/L, p < .001) were significantly lower in patients in the older donor group from day +60 to +365 after PBSCT. The EBV reactivation rate within the first 3 months after PBSCT was significantly higher in patients in the older donor group (48.6% vs. 38.3%, p = .034). However, the incidences of CMV reactivation, II‐IV acute graft‐versus‐host disease (aGvHD), chronic GvHD (cGvHD), 3‐year relapse rate, 3‐year transplant‐related mortality (TRM) and 3‐year overall survival (OS) were not significantly different between the two groups. CONCLUSION: In conclusion, donors ≥50 years old were associated with inferior immune reconstitution and higher EBV reactivation in patients after PBSCT, but no change in OS. |
format | Online Article Text |
id | pubmed-10078254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100782542023-04-07 Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors Jiang, Peiyao Cai, Yu Zhou, Xiao Yang, Jun Tong, Yin Huang, Chongmei Qiu, Huiying Zhou, Kun Xu, Xiaowei Zhang, Ying Niu, Jiahua Shen, Chang Xia, Xinxin Wei, Yu Song, Xianmin Wan, Liping Clin Transplant Original Articles BACKGROUND: The impact of donor age on the immune reconstitution of patients with hematological malignancies who underwent hematopoietic cell transplantation (HCT) is unclear. METHOD: We retrospectively compared the outcomes of 381 patients who underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from 308 donors under 50 years of age and 73 donors over 50 years of age. IVIG was regularly supplemented for patients in the first 3 months post‐HCT. RESULTS: The counts of CD8+CD45RA+ naïve T cells were significantly lower in patients of the older donor group than in the younger donor group in the first year after PBSCT (190.6 cells/μl vs. 239.6 cells/μl, p = .018). Patients in the older donor group had significantly fewer CD19+ B cells on day +270 (123.4 cells/μl vs. 183.5 cells/μl, p = .021) and day +365 (169 cells/μl vs. 271.1 cells/μl, p = .01) after PBSCT. Serum IgA (.76 g/L vs. .97 g/L, p < .001) and IgM levels (.75 g/L vs. 1.04 g/L, p < .001) were significantly lower in patients in the older donor group from day +60 to +365 after PBSCT. The EBV reactivation rate within the first 3 months after PBSCT was significantly higher in patients in the older donor group (48.6% vs. 38.3%, p = .034). However, the incidences of CMV reactivation, II‐IV acute graft‐versus‐host disease (aGvHD), chronic GvHD (cGvHD), 3‐year relapse rate, 3‐year transplant‐related mortality (TRM) and 3‐year overall survival (OS) were not significantly different between the two groups. CONCLUSION: In conclusion, donors ≥50 years old were associated with inferior immune reconstitution and higher EBV reactivation in patients after PBSCT, but no change in OS. John Wiley and Sons Inc. 2022-11-14 2023-01 /pmc/articles/PMC10078254/ /pubmed/36318732 http://dx.doi.org/10.1111/ctr.14844 Text en © 2022 The Authors. Clinical Transplantation published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Jiang, Peiyao Cai, Yu Zhou, Xiao Yang, Jun Tong, Yin Huang, Chongmei Qiu, Huiying Zhou, Kun Xu, Xiaowei Zhang, Ying Niu, Jiahua Shen, Chang Xia, Xinxin Wei, Yu Song, Xianmin Wan, Liping Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors |
title | Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors |
title_full | Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors |
title_fullStr | Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors |
title_full_unstemmed | Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors |
title_short | Immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors |
title_sort | immune reconstitution and survival of patients after allogeneic hematopoietic stem cell transplantation from older donors |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078254/ https://www.ncbi.nlm.nih.gov/pubmed/36318732 http://dx.doi.org/10.1111/ctr.14844 |
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