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A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis (CVST). This is a topic of substantial importance since current treatment modalities for CVST still fail in as many as 20% to 40% of the cases,...

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Autores principales: Zhang, Bohua, Wu, Huaiyu, Kim, Howuk, Welch, Phoebe J., Cornett, Ashley, Stocker, Greyson, Nogueira, Raul G., Kim, Jinwook, Owens, Gabe, Dayton, Paul A., Xu, Zhen, Shi, Chengzhi, Jiang, Xiaoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078321/
https://www.ncbi.nlm.nih.gov/pubmed/37040522
http://dx.doi.org/10.34133/research.0048
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author Zhang, Bohua
Wu, Huaiyu
Kim, Howuk
Welch, Phoebe J.
Cornett, Ashley
Stocker, Greyson
Nogueira, Raul G.
Kim, Jinwook
Owens, Gabe
Dayton, Paul A.
Xu, Zhen
Shi, Chengzhi
Jiang, Xiaoning
author_facet Zhang, Bohua
Wu, Huaiyu
Kim, Howuk
Welch, Phoebe J.
Cornett, Ashley
Stocker, Greyson
Nogueira, Raul G.
Kim, Jinwook
Owens, Gabe
Dayton, Paul A.
Xu, Zhen
Shi, Chengzhi
Jiang, Xiaoning
author_sort Zhang, Bohua
collection PubMed
description This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis (CVST). This is a topic of substantial importance since current treatment modalities for CVST still fail in as many as 20% to 40% of the cases, and the incidence of CVST has increased since the outbreak of the coronavirus disease 2019 pandemic. Compared with conventional anticoagulant or thrombolytic drugs, sonothrombolysis has the potential to remarkably shorten the required treatment time owing to the direct clot targeting with acoustic waves. However, previously reported strategies for sonothrombolysis have not demonstrated clinically meaningful outcomes (e.g., recanalization within 30 min) in treating large, completely occluded veins or arteries. Here, we demonstrated a new vortex ultrasound technique for endovascular sonothrombolysis utilizing wave-matter interaction-induced shear stress to enhance the lytic rate substantially. Our in vitro experiment showed that the lytic rate was increased by at least 64.3% compared with the nonvortex endovascular ultrasound treatment. A 3.1-g, 7.5-cm-long, completely occluded in vitro 3-dimensional model of acute CVST was fully recanalized within 8 min with a record-high lytic rate of 237.5 mg/min for acute bovine clot in vitro. Furthermore, we confirmed that the vortex ultrasound causes no vessel wall damage over ex vivo canine veins. This vortex ultrasound thrombolysis technique potentially presents a new life-saving tool for severe CVST cases that cannot be efficaciously treated using existing therapies.
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spelling pubmed-100783212023-04-07 A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis Zhang, Bohua Wu, Huaiyu Kim, Howuk Welch, Phoebe J. Cornett, Ashley Stocker, Greyson Nogueira, Raul G. Kim, Jinwook Owens, Gabe Dayton, Paul A. Xu, Zhen Shi, Chengzhi Jiang, Xiaoning Research (Wash D C) Research Article This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis (CVST). This is a topic of substantial importance since current treatment modalities for CVST still fail in as many as 20% to 40% of the cases, and the incidence of CVST has increased since the outbreak of the coronavirus disease 2019 pandemic. Compared with conventional anticoagulant or thrombolytic drugs, sonothrombolysis has the potential to remarkably shorten the required treatment time owing to the direct clot targeting with acoustic waves. However, previously reported strategies for sonothrombolysis have not demonstrated clinically meaningful outcomes (e.g., recanalization within 30 min) in treating large, completely occluded veins or arteries. Here, we demonstrated a new vortex ultrasound technique for endovascular sonothrombolysis utilizing wave-matter interaction-induced shear stress to enhance the lytic rate substantially. Our in vitro experiment showed that the lytic rate was increased by at least 64.3% compared with the nonvortex endovascular ultrasound treatment. A 3.1-g, 7.5-cm-long, completely occluded in vitro 3-dimensional model of acute CVST was fully recanalized within 8 min with a record-high lytic rate of 237.5 mg/min for acute bovine clot in vitro. Furthermore, we confirmed that the vortex ultrasound causes no vessel wall damage over ex vivo canine veins. This vortex ultrasound thrombolysis technique potentially presents a new life-saving tool for severe CVST cases that cannot be efficaciously treated using existing therapies. AAAS 2023-02-09 /pmc/articles/PMC10078321/ /pubmed/37040522 http://dx.doi.org/10.34133/research.0048 Text en Copyright © 2023 Bohua Zhang et al. https://creativecommons.org/licenses/by/4.0/Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Zhang, Bohua
Wu, Huaiyu
Kim, Howuk
Welch, Phoebe J.
Cornett, Ashley
Stocker, Greyson
Nogueira, Raul G.
Kim, Jinwook
Owens, Gabe
Dayton, Paul A.
Xu, Zhen
Shi, Chengzhi
Jiang, Xiaoning
A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis
title A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis
title_full A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis
title_fullStr A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis
title_full_unstemmed A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis
title_short A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis
title_sort model of high-speed endovascular sonothrombolysis with vortex ultrasound-induced shear stress to treat cerebral venous sinus thrombosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078321/
https://www.ncbi.nlm.nih.gov/pubmed/37040522
http://dx.doi.org/10.34133/research.0048
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