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C‐type lectin receptors in antifungal immunity: Current knowledge and future developments
C‐type lectin receptors (CLRs) constitute a category of innate immune receptors that play an essential role in the antifungal immune response. For over two decades, scientists have uncovered what are the fungal ligands recognized by CLRs and how these receptors initiate the immune response. Such stu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078331/ https://www.ncbi.nlm.nih.gov/pubmed/36114607 http://dx.doi.org/10.1111/pim.12951 |
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author | Hatinguais, Remi Willment, Janet A. Brown, Gordon D. |
author_facet | Hatinguais, Remi Willment, Janet A. Brown, Gordon D. |
author_sort | Hatinguais, Remi |
collection | PubMed |
description | C‐type lectin receptors (CLRs) constitute a category of innate immune receptors that play an essential role in the antifungal immune response. For over two decades, scientists have uncovered what are the fungal ligands recognized by CLRs and how these receptors initiate the immune response. Such studies have allowed the identification of genetic polymorphisms in genes encoding for CLRs or for proteins involved in the signalisation cascade they trigger. Nevertheless, our understanding of how these receptors functions and the full extent of their function during the antifungal immune response is still at its infancy. In this review, we summarize some of the main findings about CLRs in antifungal immunity and discuss what the future might hold for the field. |
format | Online Article Text |
id | pubmed-10078331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100783312023-04-07 C‐type lectin receptors in antifungal immunity: Current knowledge and future developments Hatinguais, Remi Willment, Janet A. Brown, Gordon D. Parasite Immunol Invited Reviews C‐type lectin receptors (CLRs) constitute a category of innate immune receptors that play an essential role in the antifungal immune response. For over two decades, scientists have uncovered what are the fungal ligands recognized by CLRs and how these receptors initiate the immune response. Such studies have allowed the identification of genetic polymorphisms in genes encoding for CLRs or for proteins involved in the signalisation cascade they trigger. Nevertheless, our understanding of how these receptors functions and the full extent of their function during the antifungal immune response is still at its infancy. In this review, we summarize some of the main findings about CLRs in antifungal immunity and discuss what the future might hold for the field. John Wiley and Sons Inc. 2022-10-07 2023-02 /pmc/articles/PMC10078331/ /pubmed/36114607 http://dx.doi.org/10.1111/pim.12951 Text en © 2022 The Authors. Parasite Immunology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Reviews Hatinguais, Remi Willment, Janet A. Brown, Gordon D. C‐type lectin receptors in antifungal immunity: Current knowledge and future developments |
title | C‐type lectin receptors in antifungal immunity: Current knowledge and future developments |
title_full | C‐type lectin receptors in antifungal immunity: Current knowledge and future developments |
title_fullStr | C‐type lectin receptors in antifungal immunity: Current knowledge and future developments |
title_full_unstemmed | C‐type lectin receptors in antifungal immunity: Current knowledge and future developments |
title_short | C‐type lectin receptors in antifungal immunity: Current knowledge and future developments |
title_sort | c‐type lectin receptors in antifungal immunity: current knowledge and future developments |
topic | Invited Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078331/ https://www.ncbi.nlm.nih.gov/pubmed/36114607 http://dx.doi.org/10.1111/pim.12951 |
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