Cargando…

C‐type lectin receptors in antifungal immunity: Current knowledge and future developments

C‐type lectin receptors (CLRs) constitute a category of innate immune receptors that play an essential role in the antifungal immune response. For over two decades, scientists have uncovered what are the fungal ligands recognized by CLRs and how these receptors initiate the immune response. Such stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Hatinguais, Remi, Willment, Janet A., Brown, Gordon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078331/
https://www.ncbi.nlm.nih.gov/pubmed/36114607
http://dx.doi.org/10.1111/pim.12951
_version_ 1785020494087454720
author Hatinguais, Remi
Willment, Janet A.
Brown, Gordon D.
author_facet Hatinguais, Remi
Willment, Janet A.
Brown, Gordon D.
author_sort Hatinguais, Remi
collection PubMed
description C‐type lectin receptors (CLRs) constitute a category of innate immune receptors that play an essential role in the antifungal immune response. For over two decades, scientists have uncovered what are the fungal ligands recognized by CLRs and how these receptors initiate the immune response. Such studies have allowed the identification of genetic polymorphisms in genes encoding for CLRs or for proteins involved in the signalisation cascade they trigger. Nevertheless, our understanding of how these receptors functions and the full extent of their function during the antifungal immune response is still at its infancy. In this review, we summarize some of the main findings about CLRs in antifungal immunity and discuss what the future might hold for the field.
format Online
Article
Text
id pubmed-10078331
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-100783312023-04-07 C‐type lectin receptors in antifungal immunity: Current knowledge and future developments Hatinguais, Remi Willment, Janet A. Brown, Gordon D. Parasite Immunol Invited Reviews C‐type lectin receptors (CLRs) constitute a category of innate immune receptors that play an essential role in the antifungal immune response. For over two decades, scientists have uncovered what are the fungal ligands recognized by CLRs and how these receptors initiate the immune response. Such studies have allowed the identification of genetic polymorphisms in genes encoding for CLRs or for proteins involved in the signalisation cascade they trigger. Nevertheless, our understanding of how these receptors functions and the full extent of their function during the antifungal immune response is still at its infancy. In this review, we summarize some of the main findings about CLRs in antifungal immunity and discuss what the future might hold for the field. John Wiley and Sons Inc. 2022-10-07 2023-02 /pmc/articles/PMC10078331/ /pubmed/36114607 http://dx.doi.org/10.1111/pim.12951 Text en © 2022 The Authors. Parasite Immunology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Reviews
Hatinguais, Remi
Willment, Janet A.
Brown, Gordon D.
C‐type lectin receptors in antifungal immunity: Current knowledge and future developments
title C‐type lectin receptors in antifungal immunity: Current knowledge and future developments
title_full C‐type lectin receptors in antifungal immunity: Current knowledge and future developments
title_fullStr C‐type lectin receptors in antifungal immunity: Current knowledge and future developments
title_full_unstemmed C‐type lectin receptors in antifungal immunity: Current knowledge and future developments
title_short C‐type lectin receptors in antifungal immunity: Current knowledge and future developments
title_sort c‐type lectin receptors in antifungal immunity: current knowledge and future developments
topic Invited Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078331/
https://www.ncbi.nlm.nih.gov/pubmed/36114607
http://dx.doi.org/10.1111/pim.12951
work_keys_str_mv AT hatinguaisremi ctypelectinreceptorsinantifungalimmunitycurrentknowledgeandfuturedevelopments
AT willmentjaneta ctypelectinreceptorsinantifungalimmunitycurrentknowledgeandfuturedevelopments
AT browngordond ctypelectinreceptorsinantifungalimmunitycurrentknowledgeandfuturedevelopments