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Fungal resilience and host–pathogen interactions: Future perspectives and opportunities
We are constantly exposed to the threat of fungal infection. The outcome—clearance, commensalism or infection—depends largely on the ability of our innate immune defences to clear infecting fungal cells versus the success of the fungus in mounting compensatory adaptive responses. As each seeks to ga...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078341/ https://www.ncbi.nlm.nih.gov/pubmed/35962618 http://dx.doi.org/10.1111/pim.12946 |
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author | Brown, Alistair J. P. |
author_facet | Brown, Alistair J. P. |
author_sort | Brown, Alistair J. P. |
collection | PubMed |
description | We are constantly exposed to the threat of fungal infection. The outcome—clearance, commensalism or infection—depends largely on the ability of our innate immune defences to clear infecting fungal cells versus the success of the fungus in mounting compensatory adaptive responses. As each seeks to gain advantage during these skirmishes, the interactions between host and fungal pathogen are complex and dynamic. Nevertheless, simply compromising the physiological robustness of fungal pathogens reduces their ability to evade antifungal immunity, their virulence, and their tolerance against antifungal therapy. In this article I argue that this physiological robustness is based on a ‘Resilience Network’ which mechanistically links and controls fungal growth, metabolism, stress resistance and drug tolerance. The elasticity of this network probably underlies the phenotypic variability of fungal isolates and the heterogeneity of individual cells within clonal populations. Consequently, I suggest that the definition of the fungal Resilience Network represents an important goal for the future which offers the clear potential to reveal drug targets that compromise drug tolerance and synergise with current antifungal therapies. |
format | Online Article Text |
id | pubmed-10078341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100783412023-04-07 Fungal resilience and host–pathogen interactions: Future perspectives and opportunities Brown, Alistair J. P. Parasite Immunol Invited Reviews We are constantly exposed to the threat of fungal infection. The outcome—clearance, commensalism or infection—depends largely on the ability of our innate immune defences to clear infecting fungal cells versus the success of the fungus in mounting compensatory adaptive responses. As each seeks to gain advantage during these skirmishes, the interactions between host and fungal pathogen are complex and dynamic. Nevertheless, simply compromising the physiological robustness of fungal pathogens reduces their ability to evade antifungal immunity, their virulence, and their tolerance against antifungal therapy. In this article I argue that this physiological robustness is based on a ‘Resilience Network’ which mechanistically links and controls fungal growth, metabolism, stress resistance and drug tolerance. The elasticity of this network probably underlies the phenotypic variability of fungal isolates and the heterogeneity of individual cells within clonal populations. Consequently, I suggest that the definition of the fungal Resilience Network represents an important goal for the future which offers the clear potential to reveal drug targets that compromise drug tolerance and synergise with current antifungal therapies. John Wiley and Sons Inc. 2022-08-27 2023-02 /pmc/articles/PMC10078341/ /pubmed/35962618 http://dx.doi.org/10.1111/pim.12946 Text en © 2022 The Author. Parasite Immunology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Reviews Brown, Alistair J. P. Fungal resilience and host–pathogen interactions: Future perspectives and opportunities |
title | Fungal resilience and host–pathogen interactions: Future perspectives and opportunities |
title_full | Fungal resilience and host–pathogen interactions: Future perspectives and opportunities |
title_fullStr | Fungal resilience and host–pathogen interactions: Future perspectives and opportunities |
title_full_unstemmed | Fungal resilience and host–pathogen interactions: Future perspectives and opportunities |
title_short | Fungal resilience and host–pathogen interactions: Future perspectives and opportunities |
title_sort | fungal resilience and host–pathogen interactions: future perspectives and opportunities |
topic | Invited Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078341/ https://www.ncbi.nlm.nih.gov/pubmed/35962618 http://dx.doi.org/10.1111/pim.12946 |
work_keys_str_mv | AT brownalistairjp fungalresilienceandhostpathogeninteractionsfutureperspectivesandopportunities |