Cargando…

Fungal resilience and host–pathogen interactions: Future perspectives and opportunities

We are constantly exposed to the threat of fungal infection. The outcome—clearance, commensalism or infection—depends largely on the ability of our innate immune defences to clear infecting fungal cells versus the success of the fungus in mounting compensatory adaptive responses. As each seeks to ga...

Descripción completa

Detalles Bibliográficos
Autor principal: Brown, Alistair J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078341/
https://www.ncbi.nlm.nih.gov/pubmed/35962618
http://dx.doi.org/10.1111/pim.12946
_version_ 1785020496445702144
author Brown, Alistair J. P.
author_facet Brown, Alistair J. P.
author_sort Brown, Alistair J. P.
collection PubMed
description We are constantly exposed to the threat of fungal infection. The outcome—clearance, commensalism or infection—depends largely on the ability of our innate immune defences to clear infecting fungal cells versus the success of the fungus in mounting compensatory adaptive responses. As each seeks to gain advantage during these skirmishes, the interactions between host and fungal pathogen are complex and dynamic. Nevertheless, simply compromising the physiological robustness of fungal pathogens reduces their ability to evade antifungal immunity, their virulence, and their tolerance against antifungal therapy. In this article I argue that this physiological robustness is based on a ‘Resilience Network’ which mechanistically links and controls fungal growth, metabolism, stress resistance and drug tolerance. The elasticity of this network probably underlies the phenotypic variability of fungal isolates and the heterogeneity of individual cells within clonal populations. Consequently, I suggest that the definition of the fungal Resilience Network represents an important goal for the future which offers the clear potential to reveal drug targets that compromise drug tolerance and synergise with current antifungal therapies.
format Online
Article
Text
id pubmed-10078341
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-100783412023-04-07 Fungal resilience and host–pathogen interactions: Future perspectives and opportunities Brown, Alistair J. P. Parasite Immunol Invited Reviews We are constantly exposed to the threat of fungal infection. The outcome—clearance, commensalism or infection—depends largely on the ability of our innate immune defences to clear infecting fungal cells versus the success of the fungus in mounting compensatory adaptive responses. As each seeks to gain advantage during these skirmishes, the interactions between host and fungal pathogen are complex and dynamic. Nevertheless, simply compromising the physiological robustness of fungal pathogens reduces their ability to evade antifungal immunity, their virulence, and their tolerance against antifungal therapy. In this article I argue that this physiological robustness is based on a ‘Resilience Network’ which mechanistically links and controls fungal growth, metabolism, stress resistance and drug tolerance. The elasticity of this network probably underlies the phenotypic variability of fungal isolates and the heterogeneity of individual cells within clonal populations. Consequently, I suggest that the definition of the fungal Resilience Network represents an important goal for the future which offers the clear potential to reveal drug targets that compromise drug tolerance and synergise with current antifungal therapies. John Wiley and Sons Inc. 2022-08-27 2023-02 /pmc/articles/PMC10078341/ /pubmed/35962618 http://dx.doi.org/10.1111/pim.12946 Text en © 2022 The Author. Parasite Immunology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Reviews
Brown, Alistair J. P.
Fungal resilience and host–pathogen interactions: Future perspectives and opportunities
title Fungal resilience and host–pathogen interactions: Future perspectives and opportunities
title_full Fungal resilience and host–pathogen interactions: Future perspectives and opportunities
title_fullStr Fungal resilience and host–pathogen interactions: Future perspectives and opportunities
title_full_unstemmed Fungal resilience and host–pathogen interactions: Future perspectives and opportunities
title_short Fungal resilience and host–pathogen interactions: Future perspectives and opportunities
title_sort fungal resilience and host–pathogen interactions: future perspectives and opportunities
topic Invited Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078341/
https://www.ncbi.nlm.nih.gov/pubmed/35962618
http://dx.doi.org/10.1111/pim.12946
work_keys_str_mv AT brownalistairjp fungalresilienceandhostpathogeninteractionsfutureperspectivesandopportunities