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Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study

AIMS: Visceral adiposity and skeletal muscle loss may be positively correlated with cardiometabolic outcomes. This study aimed to explore the associations between the visceral fat area to skeletal muscle mass ratio (VSR) and the risk of cardiometabolic diseases in a Chinese natural population. MATER...

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Autores principales: Zhang, Shi, Huang, Yaping, Li, Jing, Wang, Xincheng, Wang, Xiaohe, Zhang, Minying, Zhang, Yanju, Du, Meiyang, Lin, Jingna, Li, Chunjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078378/
https://www.ncbi.nlm.nih.gov/pubmed/36426681
http://dx.doi.org/10.1002/dmrr.3597
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author Zhang, Shi
Huang, Yaping
Li, Jing
Wang, Xincheng
Wang, Xiaohe
Zhang, Minying
Zhang, Yanju
Du, Meiyang
Lin, Jingna
Li, Chunjun
author_facet Zhang, Shi
Huang, Yaping
Li, Jing
Wang, Xincheng
Wang, Xiaohe
Zhang, Minying
Zhang, Yanju
Du, Meiyang
Lin, Jingna
Li, Chunjun
author_sort Zhang, Shi
collection PubMed
description AIMS: Visceral adiposity and skeletal muscle loss may be positively correlated with cardiometabolic outcomes. This study aimed to explore the associations between the visceral fat area to skeletal muscle mass ratio (VSR) and the risk of cardiometabolic diseases in a Chinese natural population. MATERIALS AND METHODS: A total of 5158 participants were included in this study. Body composition, anthropometrical, and biochemical measurements were performed. Body composition was assessed via the direct segmental multi‐frequency bioelectrical impedance analysis method. The associations between VSR and metabolic associated fatty liver disease (MAFLD), hyperglycemia, hypertension, dyslipidemia, and hyperuricemia were analysed. RESULTS: With the increase of VSR by one quartile, the odds ratio (OR) increased significantly for all five cardiometabolic diseases in both genders (p (trend) < 0.001). With regard to the highest versus the lowest quartile of VSR, the ORs for cardiometabolic diseases were significantly higher in women than in men. Restricted cubic splines showed that there were significant non‐linear relationships between VSR and the risk of MAFLD, dyslipidemia, hyperglycemia, and hypertension in both genders (p for non‐linearity <0.05). The risk was relatively flat until VSR reached 3.078 cm(2)/kg in men and 4.750 cm(2)/kg in women and started to increase rapidly afterwards. In men, however, the risk slowed down after the VSR value reached around 4 cm(2)/kg. CONCLUSIONS: VSR was positively associated with cardiometabolic diseases regardless of gender. As VSR increased, the risk of cardiometabolic diseases was significantly higher in women than in men. TRIAL REGISTRATION: www.chictr.org.cn (Registration number: ChiCTR2100044305).
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spelling pubmed-100783782023-04-07 Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study Zhang, Shi Huang, Yaping Li, Jing Wang, Xincheng Wang, Xiaohe Zhang, Minying Zhang, Yanju Du, Meiyang Lin, Jingna Li, Chunjun Diabetes Metab Res Rev Research Articles AIMS: Visceral adiposity and skeletal muscle loss may be positively correlated with cardiometabolic outcomes. This study aimed to explore the associations between the visceral fat area to skeletal muscle mass ratio (VSR) and the risk of cardiometabolic diseases in a Chinese natural population. MATERIALS AND METHODS: A total of 5158 participants were included in this study. Body composition, anthropometrical, and biochemical measurements were performed. Body composition was assessed via the direct segmental multi‐frequency bioelectrical impedance analysis method. The associations between VSR and metabolic associated fatty liver disease (MAFLD), hyperglycemia, hypertension, dyslipidemia, and hyperuricemia were analysed. RESULTS: With the increase of VSR by one quartile, the odds ratio (OR) increased significantly for all five cardiometabolic diseases in both genders (p (trend) < 0.001). With regard to the highest versus the lowest quartile of VSR, the ORs for cardiometabolic diseases were significantly higher in women than in men. Restricted cubic splines showed that there were significant non‐linear relationships between VSR and the risk of MAFLD, dyslipidemia, hyperglycemia, and hypertension in both genders (p for non‐linearity <0.05). The risk was relatively flat until VSR reached 3.078 cm(2)/kg in men and 4.750 cm(2)/kg in women and started to increase rapidly afterwards. In men, however, the risk slowed down after the VSR value reached around 4 cm(2)/kg. CONCLUSIONS: VSR was positively associated with cardiometabolic diseases regardless of gender. As VSR increased, the risk of cardiometabolic diseases was significantly higher in women than in men. TRIAL REGISTRATION: www.chictr.org.cn (Registration number: ChiCTR2100044305). John Wiley and Sons Inc. 2022-12-02 2023-02 /pmc/articles/PMC10078378/ /pubmed/36426681 http://dx.doi.org/10.1002/dmrr.3597 Text en © 2022 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Zhang, Shi
Huang, Yaping
Li, Jing
Wang, Xincheng
Wang, Xiaohe
Zhang, Minying
Zhang, Yanju
Du, Meiyang
Lin, Jingna
Li, Chunjun
Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study
title Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study
title_full Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study
title_fullStr Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study
title_full_unstemmed Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study
title_short Increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a Chinese natural population: A cross‐sectional study
title_sort increased visceral fat area to skeletal muscle mass ratio is positively associated with the risk of cardiometabolic diseases in a chinese natural population: a cross‐sectional study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078378/
https://www.ncbi.nlm.nih.gov/pubmed/36426681
http://dx.doi.org/10.1002/dmrr.3597
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