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Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

A deep in silico investigation of various microsomal prostaglandin E(2) synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely t...

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Detalles Bibliográficos
Autores principales:	Di Micco, Simone, Lauro, Gianluigi, Bifulco, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078397/ https://www.ncbi.nlm.nih.gov/pubmed/36075865 http://dx.doi.org/10.1002/minf.202200140

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