The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution

BACKGROUND: Growth inhibition by RPR-130401, a non-peptidomimetic farnesyltransferase inhibitor, was investigated without or with combined exposure to ionizing radiation in three human tumor cell lines (HCT-116, MiAPaCa-2 and A-549) bearing a point mutation in the K-Ras gene. RESULTS: RPR-130401 inh...

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Detalles Bibliográficos
Autores principales: Mégnin-Chanet, Frédérique, Lavelle, François, Favaudon, Vincent
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC100785/
https://www.ncbi.nlm.nih.gov/pubmed/11929613
http://dx.doi.org/10.1186/1471-2210-2-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC100785/
https://www.ncbi.nlm.nih.gov/pubmed/11929613
http://dx.doi.org/10.1186/1471-2210-2-2

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