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Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving

Tobacco smoking is associated with deleterious health outcomes. Most smokers want to quit smoking, yet relapse rates are high. Understanding neural differences associated with tobacco use may help generate novel treatment options. Several animal studies have recently highlighted the central role of...

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Autores principales: Lor, Cindy Sumaly, Haugg, Amelie, Zhang, Mengfan, Schneider, Letitia, Herdener, Marcus, Quednow, Boris B., Golestani, Narly, Scharnowski, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078543/
https://www.ncbi.nlm.nih.gov/pubmed/36577730
http://dx.doi.org/10.1111/adb.13261
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author Lor, Cindy Sumaly
Haugg, Amelie
Zhang, Mengfan
Schneider, Letitia
Herdener, Marcus
Quednow, Boris B.
Golestani, Narly
Scharnowski, Frank
author_facet Lor, Cindy Sumaly
Haugg, Amelie
Zhang, Mengfan
Schneider, Letitia
Herdener, Marcus
Quednow, Boris B.
Golestani, Narly
Scharnowski, Frank
author_sort Lor, Cindy Sumaly
collection PubMed
description Tobacco smoking is associated with deleterious health outcomes. Most smokers want to quit smoking, yet relapse rates are high. Understanding neural differences associated with tobacco use may help generate novel treatment options. Several animal studies have recently highlighted the central role of the thalamus in substance use disorders, but this research focus has been understudied in human smokers. Here, we investigated associations between structural and functional magnetic resonance imaging measures of the thalamus and its subnuclei to distinct smoking characteristics. We acquired anatomical scans of 32 smokers as well as functional resting‐state scans before and after a cue‐reactivity task. Thalamic functional connectivity was associated with craving and dependence severity, whereas the volume of the thalamus was associated with dependence severity only. Craving, which fluctuates rapidly, was best characterized by differences in brain function, whereas the rather persistent syndrome of dependence severity was associated with both brain structural differences and function. Our study supports the notion that functional versus structural measures tend to be associated with behavioural measures that evolve at faster versus slower temporal scales, respectively. It confirms the importance of the thalamus to understand mechanisms of addiction and highlights it as a potential target for brain‐based interventions to support smoking cessation, such as brain stimulation and neurofeedback.
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spelling pubmed-100785432023-04-07 Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving Lor, Cindy Sumaly Haugg, Amelie Zhang, Mengfan Schneider, Letitia Herdener, Marcus Quednow, Boris B. Golestani, Narly Scharnowski, Frank Addict Biol Original Articles Tobacco smoking is associated with deleterious health outcomes. Most smokers want to quit smoking, yet relapse rates are high. Understanding neural differences associated with tobacco use may help generate novel treatment options. Several animal studies have recently highlighted the central role of the thalamus in substance use disorders, but this research focus has been understudied in human smokers. Here, we investigated associations between structural and functional magnetic resonance imaging measures of the thalamus and its subnuclei to distinct smoking characteristics. We acquired anatomical scans of 32 smokers as well as functional resting‐state scans before and after a cue‐reactivity task. Thalamic functional connectivity was associated with craving and dependence severity, whereas the volume of the thalamus was associated with dependence severity only. Craving, which fluctuates rapidly, was best characterized by differences in brain function, whereas the rather persistent syndrome of dependence severity was associated with both brain structural differences and function. Our study supports the notion that functional versus structural measures tend to be associated with behavioural measures that evolve at faster versus slower temporal scales, respectively. It confirms the importance of the thalamus to understand mechanisms of addiction and highlights it as a potential target for brain‐based interventions to support smoking cessation, such as brain stimulation and neurofeedback. John Wiley and Sons Inc. 2022-11-30 2023-01 /pmc/articles/PMC10078543/ /pubmed/36577730 http://dx.doi.org/10.1111/adb.13261 Text en © 2022 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Lor, Cindy Sumaly
Haugg, Amelie
Zhang, Mengfan
Schneider, Letitia
Herdener, Marcus
Quednow, Boris B.
Golestani, Narly
Scharnowski, Frank
Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving
title Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving
title_full Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving
title_fullStr Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving
title_full_unstemmed Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving
title_short Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving
title_sort thalamic volume and functional connectivity are associated with nicotine dependence severity and craving
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078543/
https://www.ncbi.nlm.nih.gov/pubmed/36577730
http://dx.doi.org/10.1111/adb.13261
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