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Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals
INTRODUCTION: We report dementia incidence, comorbidities, reasons for health‐care visits, mortality, causes of death, and examined dementia patterns by relative deprivation in the UK. METHOD: A longitudinal cohort analysis of linked electronic health records from 4.3 million people in the UK was co...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078672/ https://www.ncbi.nlm.nih.gov/pubmed/35290719 http://dx.doi.org/10.1002/alz.12635 |
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author | Chung, Sheng‐Chia Providencia, Rui Sofat, Reecha Pujades‐Rodriguez, Mar Torralbo, Ana Fatemifar, Ghazaleh Fitzpatrick, Natalie K. Taylor, Julie Li, Ken Dale, Caroline Rossor, Martin Acosta‐Mena, Dionisio Whittaker, John Denaxas, Spiros |
author_facet | Chung, Sheng‐Chia Providencia, Rui Sofat, Reecha Pujades‐Rodriguez, Mar Torralbo, Ana Fatemifar, Ghazaleh Fitzpatrick, Natalie K. Taylor, Julie Li, Ken Dale, Caroline Rossor, Martin Acosta‐Mena, Dionisio Whittaker, John Denaxas, Spiros |
author_sort | Chung, Sheng‐Chia |
collection | PubMed |
description | INTRODUCTION: We report dementia incidence, comorbidities, reasons for health‐care visits, mortality, causes of death, and examined dementia patterns by relative deprivation in the UK. METHOD: A longitudinal cohort analysis of linked electronic health records from 4.3 million people in the UK was conducted to investigate dementia incidence and mortality. Reasons for hospitalization and causes of death were compared in individuals with and without dementia. RESULTS: From 1998 to 2016 we observed 145,319 (3.1%) individuals with incident dementia. Repeated hospitalizations among senior adults for infection, unknown morbidity, and multiple primary care visits for chronic pain were observed prior to dementia diagnosis. Multiple long‐term conditions are present in half of the individuals at the time of diagnosis. Individuals living in high deprivation areas had higher dementia incidence and high fatality. DISCUSSION: There is a considerable disparity of dementia that informs priorities of prevention and provision of patient care. |
format | Online Article Text |
id | pubmed-10078672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100786722023-04-07 Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals Chung, Sheng‐Chia Providencia, Rui Sofat, Reecha Pujades‐Rodriguez, Mar Torralbo, Ana Fatemifar, Ghazaleh Fitzpatrick, Natalie K. Taylor, Julie Li, Ken Dale, Caroline Rossor, Martin Acosta‐Mena, Dionisio Whittaker, John Denaxas, Spiros Alzheimers Dement Featured Articles INTRODUCTION: We report dementia incidence, comorbidities, reasons for health‐care visits, mortality, causes of death, and examined dementia patterns by relative deprivation in the UK. METHOD: A longitudinal cohort analysis of linked electronic health records from 4.3 million people in the UK was conducted to investigate dementia incidence and mortality. Reasons for hospitalization and causes of death were compared in individuals with and without dementia. RESULTS: From 1998 to 2016 we observed 145,319 (3.1%) individuals with incident dementia. Repeated hospitalizations among senior adults for infection, unknown morbidity, and multiple primary care visits for chronic pain were observed prior to dementia diagnosis. Multiple long‐term conditions are present in half of the individuals at the time of diagnosis. Individuals living in high deprivation areas had higher dementia incidence and high fatality. DISCUSSION: There is a considerable disparity of dementia that informs priorities of prevention and provision of patient care. John Wiley and Sons Inc. 2022-03-15 2023-01 /pmc/articles/PMC10078672/ /pubmed/35290719 http://dx.doi.org/10.1002/alz.12635 Text en © 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Featured Articles Chung, Sheng‐Chia Providencia, Rui Sofat, Reecha Pujades‐Rodriguez, Mar Torralbo, Ana Fatemifar, Ghazaleh Fitzpatrick, Natalie K. Taylor, Julie Li, Ken Dale, Caroline Rossor, Martin Acosta‐Mena, Dionisio Whittaker, John Denaxas, Spiros Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals |
title | Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals |
title_full | Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals |
title_fullStr | Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals |
title_full_unstemmed | Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals |
title_short | Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals |
title_sort | incidence, morbidity, mortality and disparities in dementia: a population linked electronic health records study of 4.3 million individuals |
topic | Featured Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078672/ https://www.ncbi.nlm.nih.gov/pubmed/35290719 http://dx.doi.org/10.1002/alz.12635 |
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