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Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals

INTRODUCTION: We report dementia incidence, comorbidities, reasons for health‐care visits, mortality, causes of death, and examined dementia patterns by relative deprivation in the UK. METHOD: A longitudinal cohort analysis of linked electronic health records from 4.3 million people in the UK was co...

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Autores principales: Chung, Sheng‐Chia, Providencia, Rui, Sofat, Reecha, Pujades‐Rodriguez, Mar, Torralbo, Ana, Fatemifar, Ghazaleh, Fitzpatrick, Natalie K., Taylor, Julie, Li, Ken, Dale, Caroline, Rossor, Martin, Acosta‐Mena, Dionisio, Whittaker, John, Denaxas, Spiros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078672/
https://www.ncbi.nlm.nih.gov/pubmed/35290719
http://dx.doi.org/10.1002/alz.12635
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author Chung, Sheng‐Chia
Providencia, Rui
Sofat, Reecha
Pujades‐Rodriguez, Mar
Torralbo, Ana
Fatemifar, Ghazaleh
Fitzpatrick, Natalie K.
Taylor, Julie
Li, Ken
Dale, Caroline
Rossor, Martin
Acosta‐Mena, Dionisio
Whittaker, John
Denaxas, Spiros
author_facet Chung, Sheng‐Chia
Providencia, Rui
Sofat, Reecha
Pujades‐Rodriguez, Mar
Torralbo, Ana
Fatemifar, Ghazaleh
Fitzpatrick, Natalie K.
Taylor, Julie
Li, Ken
Dale, Caroline
Rossor, Martin
Acosta‐Mena, Dionisio
Whittaker, John
Denaxas, Spiros
author_sort Chung, Sheng‐Chia
collection PubMed
description INTRODUCTION: We report dementia incidence, comorbidities, reasons for health‐care visits, mortality, causes of death, and examined dementia patterns by relative deprivation in the UK. METHOD: A longitudinal cohort analysis of linked electronic health records from 4.3 million people in the UK was conducted to investigate dementia incidence and mortality. Reasons for hospitalization and causes of death were compared in individuals with and without dementia. RESULTS: From 1998 to 2016 we observed 145,319 (3.1%) individuals with incident dementia. Repeated hospitalizations among senior adults for infection, unknown morbidity, and multiple primary care visits for chronic pain were observed prior to dementia diagnosis. Multiple long‐term conditions are present in half of the individuals at the time of diagnosis. Individuals living in high deprivation areas had higher dementia incidence and high fatality. DISCUSSION: There is a considerable disparity of dementia that informs priorities of prevention and provision of patient care.
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spelling pubmed-100786722023-04-07 Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals Chung, Sheng‐Chia Providencia, Rui Sofat, Reecha Pujades‐Rodriguez, Mar Torralbo, Ana Fatemifar, Ghazaleh Fitzpatrick, Natalie K. Taylor, Julie Li, Ken Dale, Caroline Rossor, Martin Acosta‐Mena, Dionisio Whittaker, John Denaxas, Spiros Alzheimers Dement Featured Articles INTRODUCTION: We report dementia incidence, comorbidities, reasons for health‐care visits, mortality, causes of death, and examined dementia patterns by relative deprivation in the UK. METHOD: A longitudinal cohort analysis of linked electronic health records from 4.3 million people in the UK was conducted to investigate dementia incidence and mortality. Reasons for hospitalization and causes of death were compared in individuals with and without dementia. RESULTS: From 1998 to 2016 we observed 145,319 (3.1%) individuals with incident dementia. Repeated hospitalizations among senior adults for infection, unknown morbidity, and multiple primary care visits for chronic pain were observed prior to dementia diagnosis. Multiple long‐term conditions are present in half of the individuals at the time of diagnosis. Individuals living in high deprivation areas had higher dementia incidence and high fatality. DISCUSSION: There is a considerable disparity of dementia that informs priorities of prevention and provision of patient care. John Wiley and Sons Inc. 2022-03-15 2023-01 /pmc/articles/PMC10078672/ /pubmed/35290719 http://dx.doi.org/10.1002/alz.12635 Text en © 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Featured Articles
Chung, Sheng‐Chia
Providencia, Rui
Sofat, Reecha
Pujades‐Rodriguez, Mar
Torralbo, Ana
Fatemifar, Ghazaleh
Fitzpatrick, Natalie K.
Taylor, Julie
Li, Ken
Dale, Caroline
Rossor, Martin
Acosta‐Mena, Dionisio
Whittaker, John
Denaxas, Spiros
Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals
title Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals
title_full Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals
title_fullStr Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals
title_full_unstemmed Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals
title_short Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals
title_sort incidence, morbidity, mortality and disparities in dementia: a population linked electronic health records study of 4.3 million individuals
topic Featured Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078672/
https://www.ncbi.nlm.nih.gov/pubmed/35290719
http://dx.doi.org/10.1002/alz.12635
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