The PASTIS trial: Testing tadalafil for possible use in vascular cognitive impairment

INTRODUCTION: There are few randomized clinical trials in vascular cognitive impairment (VCI). This trial tested the hypothesis that the PDE5 inhibitor tadalafil, a widely used vasodilator, increases cerebral blood flow (CBF) in older people with symptomatic small vessel disease, the main cause of V...

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Detalles Bibliográficos
Autores principales: Pauls, Mathilde M.H., Binnie, Lauren R., Benjamin, Philip, Betteridge, Shai, Clarke, Brian, Dhillon, Mohani‐Preet K., Ghatala, Rita, Hainsworth, Fearghal A.H., Howe, Franklyn A., Khan, Usman, Kruuse, Christina, Madigan, Jeremy B., Moynihan, Barry, Patel, Bhavini, Pereira, Anthony C., Rostrup, Egill, Shtaya, Anan B.Y., Spilling, Catherine A., Trippier, Sarah, Williams, Rebecca, Young, Robin, Barrick, Thomas R., Isaacs, Jeremy D., Hainsworth, Atticus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078742/
https://www.ncbi.nlm.nih.gov/pubmed/35135037
http://dx.doi.org/10.1002/alz.12559

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