Cargando…

Combined therapy with methotrexate nanoconjugate and dendritic cells with downregulated IL-10R expression modulates the tumor microenvironment and enhances the systemic anti-tumor immune response in MC38 murine colon carcinoma

BACKGROUND: Understanding the negative impact of the tumor microenvironment on the creation of an effective immune response has contributed to the development of new therapeutic anti-cancer strategies. One such solution is combined therapy consisting of chemotherapeutic administration followed by de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Szczygieł, Agnieszka, Węgierek-Ciura, Katarzyna, Wróblewska, Anna, Mierzejewska, Jagoda, Rossowska, Joanna, Szermer-Olearnik, Bożena, Świtalska, Marta, Anger-Góra, Natalia, Goszczyński, Tomasz M., Pajtasz-Piasecka, Elżbieta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078943/ https://www.ncbi.nlm.nih.gov/pubmed/37033926 http://dx.doi.org/10.3389/fimmu.2023.1155377

Ejemplares similares

Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines
por: Węgierek-Ciura, Katarzyna, et al.
Publicado: (2023)

Immunomodulatory potential of anticancer therapy composed of methotrexate nanoconjugate and dendritic cell-based vaccines in murine colon carcinoma
por: Szczygieł, Agnieszka, et al.
Publicado: (2021)

The Beneficial Effect of IL-12 and IL-18 Transduced Dendritic Cells Stimulated with Tumor Antigens on Generation of an Antitumor Response in a Mouse Colon Carcinoma Model
por: Mierzejewska, Jagoda, et al.
Publicado: (2022)

Antitumor Potential of Extracellular Vesicles Released by Genetically Modified Murine Colon Carcinoma Cells With Overexpression of Interleukin-12 and shRNA for TGF-β1
por: Rossowska, Joanna, et al.
Publicado: (2019)

Treatment with lentiviral vectors encoding shRNA against interleukin 10 modulates the immunosuppressive activity of murine colon carcinoma-associated myeloid-derived suppressor cells
por: Anger-Góra, Natalia, et al.
Publicado: (2021)

Synthesis and Characterization of Boron Carbide Nanoparticles as Potential Boron-Rich Therapeutic Carriers
por: Kozień, Dawid, et al.
Publicado: (2023)

Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy
por: Wróblewska, Anna, et al.
Publicado: (2023)

Reprogramming the murine colon cancer microenvironment using lentivectors encoding shRNA against IL-10 as a component of a potent DC-based chemoimmunotherapy
por: Rossowska, Joanna, et al.
Publicado: (2018)

Intratumoral Lentivector-Mediated TGF-β1 Gene Downregulation As a Potent Strategy for Enhancing the Antitumor Effect of Therapy Composed of Cyclophosphamide and Dendritic Cells
por: Rossowska, Joanna, et al.
Publicado: (2017)

Boron-Rich Boron Carbide Nanoparticles as a Carrier in Boron Neutron Capture Therapy: Their Influence on Tumor and Immune Phagocytic Cells
por: Kozień, Dawid, et al.
Publicado: (2021)

Oral Administration of Polymyxin B Modulates the Activity of Lipooligosaccharide E. coli B against Lung Metastases in Murine Tumor Models
por: Kicielińska, Jagoda, et al.
Publicado: (2016)

Treatment with cyclophosphamide supported by various dendritic cell-based vaccines induces diversification in CD4(+) T cell response against MC38 colon carcinoma
por: WOJAS-TUREK, JUSTYNA, et al.
Publicado: (2015)

Removal of Endotoxins from Bacteriophage Preparations by Extraction with Organic Solvents
por: Szermer-Olearnik, Bożena, et al.
Publicado: (2015)

The role of immune cell subpopulations in the growth and rejection of TC-1/A9 tumors in novel mouse strains differing in the H2-D haplotype and NKC domain
por: Indrová, Marie, et al.
Publicado: (2018)

New Insights on the Feature and Function of Tail Tubular Protein B and Tail Fiber Protein of the Lytic Bacteriophage φYeO3-12 Specific for Yersinia enterocolitica Serotype O:3
por: Pyra, Anna, et al.
Publicado: (2020)

Bacteriophage Tail Proteins as a Tool for Bacterial Pathogen Recognition—A Literature Review
por: Filik, Karolina, et al.
Publicado: (2022)

Structural and immunomodulatory differences among lactobacilli exopolysaccharides isolated from intestines of mice with experimentally induced inflammatory bowel disease
por: Górska, Sabina, et al.
Publicado: (2016)

Coordination of Nanoconjugation with an Antigen/Antibody for Efficient Detection of Gynecological Tumors
por: Liu, Xinmei, et al.
Publicado: (2020)

Aggregation/dispersion transitions of T4 phage triggered by environmental ion availability
por: Szermer-Olearnik, Bożena, et al.
Publicado: (2017)

Monosubstituted Acetophenone Thiosemicarbazones as Potent Inhibitors of Tyrosinase: Synthesis, Inhibitory Studies, and Molecular Docking
por: Hałdys, Katarzyna, et al.
Publicado: (2021)

A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy
por: Kim, Hyung Shik, et al.
Publicado: (2022)

Time-Prolonged Release of Tumor-Targeted Protein–MMAE Nanoconjugates from Implantable Hybrid Materials
por: Serna, Naroa, et al.
Publicado: (2022)

Dual targeting of folate receptor-expressing glioma tumor-associated macrophages and epithelial cells in the brain using a carbon nanosphere–cationic folate nanoconjugate
por: Elechalawar, Chandra Kumar, et al.
Publicado: (2019)

Gel Electrophoresis of Gold-DNA Nanoconjugates
por: Pellegrino, T., et al.
Publicado: (2007)

Porphyrin-magnetite nanoconjugates for biological imaging
por: Nowostawska, Małgorzata, et al.
Publicado: (2011)

φYeO3-12 phage tail fiber Gp17 as a promising high specific tool for recognition of Yersinia enterocolitica pathogenic serotype O:3
por: Filik, Karolina, et al.
Publicado: (2022)

T4 Phage and Its Head Surface Proteins Do Not Stimulate Inflammatory Mediator Production
por: Miernikiewicz, Paulina, et al.
Publicado: (2013)

Quantum dot/glycol chitosan fluorescent nanoconjugates
por: Mansur, Alexandra AP, et al.
Publicado: (2015)

MC38 Tumors Induce Musculoskeletal Defects in Colorectal Cancer
por: Huot, Joshua R., et al.
Publicado: (2021)

Hydroxyethyl starch as an effective methotrexate carrier in anticancer therapy
por: Goszczyński, T M, et al.
Publicado: (2014)

Curcumin Ag nanoconjugates for improved therapeutic effects in cancer
por: Shah, Darshini, et al.
Publicado: (2018)

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates
por: Duro-Castano, A., et al.
Publicado: (2021)

Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds
por: Alamoudi, Abdullah A., et al.
Publicado: (2022)

Metal-Polymer Nanoconjugates Application in Cancer Imaging and Therapy
por: Figueiredo, André Q., et al.
Publicado: (2022)

Zinc Oxide Nanoconjugates against Brain-Eating Amoebae
por: Siddiqui, Ruqaiyyah, et al.
Publicado: (2022)

Preparation of poly(β-L-malic acid)-based charge-conversional nanoconjugates for tumor-specific uptake and cellular delivery
por: Zhou, Qing, et al.
Publicado: (2015)

A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate
por: Unnikrishnan, B. S., et al.
Publicado: (2021)

Quantitative Analysis of PMLA Nanoconjugate Components after Backbone Cleavage
por: Ding, Hui, et al.
Publicado: (2015)

Nanoconjugates-Based Stem Cell Therapy for the Management of COVID-19
por: Desai, Drashti, et al.
Publicado: (2020)

The specific T-cell response to antigenic peptides is influenced by bystander peptides
por: Nowak, Izabela, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_koprvi764stv2eiv895v8nmtl4