An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity

Aggressive tumors often display mitochondrial dysfunction. Upon oxidative stress, mitochondria undergo fission through OMA1-mediated cleavage of the fusion effector OPA1. In yeast, a redox-sensing switch participates in OMA1 activation. 3D modeling of OMA1 comforted the notion that cysteine 403 migh...

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Detalles Bibliográficos
Autores principales: Miallot, Richard, Millet, Virginie, Groult, Yann, Modelska, Angelika, Crescence, Lydie, Roulland, Sandrine, Henri, Sandrine, Malissen, Bernard, Brouilly, Nicolas, Panicot-Dubois, Laurence, Vincentelli, Renaud, Sulzenbacher, Gerlind, Finetti, Pascal, Dutour, Aurélie, Blay, Jean-Yves, Bertucci, François, Galland, Franck, Naquet, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078952/
https://www.ncbi.nlm.nih.gov/pubmed/37024121
http://dx.doi.org/10.26508/lsa.202201767

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