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Issues with RNF43 antibodies to reliably detect intracellular location
RNF43 is an important negative regulator of β-catenin signaling by removing Wnt-receptors from the membrane. It is often mutated in cancers, leading to aberrant Wnt-dependent nuclear translocation of β-catenin. RNF43 has also been suggested to regulate β-catenin signaling directly within the nucleus...
Autores principales: | Li, Shanshan, Zhang, Ruyi, Lavrijsen, Marla, van den Bosch, Thierry P. P., Peppelenbosch, Maikel P., Smits, Ron |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079101/ https://www.ncbi.nlm.nih.gov/pubmed/37023034 http://dx.doi.org/10.1371/journal.pone.0283894 |
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