Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection

Serine proteases (SP), including furin, trypsin, and TMPRSS2 cleave the SARS-CoV-2 spike (S) protein, enabling the virus to enter cells. Here, we show that factor (F) Xa, an SP involved in blood coagulation, is upregulated in COVID-19 patients. In contrast to other SPs, FXa exerts antiviral activity...

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Detalles Bibliográficos
Autores principales: Dong, Wenjuan, Wang, Jing, Tian, Lei, Zhang, Jianying, Settles, Erik W., Qin, Chao, Steinken-Kollath, Daniel R., Itogawa, Ashley N., Celona, Kimberly R., Yi, Jinhee, Bryant, Mitchell, Mead, Heather, Jaramillo, Sierra A., Lu, Hongjia, Li, Aimin, Zumwalt, Ross E., Dadwal, Sanjeet, Feng, Pinghui, Yuan, Weiming, Whelan, Sean P. J., Keim, Paul S., Barker, Bridget Marie, Caligiuri, Michael A., Yu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079155/
https://www.ncbi.nlm.nih.gov/pubmed/37024459
http://dx.doi.org/10.1038/s41467-023-37336-9

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