Discovery of Hippo signaling as a regulator of CSPG4 expression and as a therapeutic target for Clostridioides difficile disease

The signaling pathways and networks regulating expression of chondroitin sulfate proteoglycan 4 (CSPG4), a cancer-related protein that serves as a receptor for Clostridiodes difficile TcdB, are poorly defined. In this study, TcdB-resistant/CSPG4-negative HeLa cells were generated by exposure to incr...

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Detalles Bibliográficos
Autores principales: Larabee, Jason L., Doyle, D. Annie, Ahmed, Ummey Khalecha Bintha, Shadid, Tyler M., Sharp, Rachel R., Jones, Kenneth L., Kim, Young Mi, Li, Shibo, Ballard, Jimmy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079225/
https://www.ncbi.nlm.nih.gov/pubmed/36972308
http://dx.doi.org/10.1371/journal.ppat.1011272

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