Cargando…
COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are continuously facing huge problems in the treatment of patients, as COVID-19-specific drugs are not available, hence the principle of drug repurposing serves as a one-and-only hope. Gl...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079314/ https://www.ncbi.nlm.nih.gov/pubmed/37334160 http://dx.doi.org/10.1016/j.gendis.2022.12.019 |
_version_ | 1785020701926752256 |
---|---|
author | Kumar, Sunny Basu, Malini Ghosh, Pratyasha Pal, Uttam Ghosh, Mrinal K. |
author_facet | Kumar, Sunny Basu, Malini Ghosh, Pratyasha Pal, Uttam Ghosh, Mrinal K. |
author_sort | Kumar, Sunny |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are continuously facing huge problems in the treatment of patients, as COVID-19-specific drugs are not available, hence the principle of drug repurposing serves as a one-and-only hope. Globally, the repurposing of many drugs is underway; few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical trials. Here in this review, our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs, the potential mechanism of actions, and the current clinical trial status of various drugs which are under repurposing since early 2020. At last, we briefly proposed the probable pharmacological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines. |
format | Online Article Text |
id | pubmed-10079314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-100793142023-04-07 COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery Kumar, Sunny Basu, Malini Ghosh, Pratyasha Pal, Uttam Ghosh, Mrinal K. Genes Dis Review Article Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are continuously facing huge problems in the treatment of patients, as COVID-19-specific drugs are not available, hence the principle of drug repurposing serves as a one-and-only hope. Globally, the repurposing of many drugs is underway; few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical trials. Here in this review, our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs, the potential mechanism of actions, and the current clinical trial status of various drugs which are under repurposing since early 2020. At last, we briefly proposed the probable pharmacological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines. Chongqing Medical University 2023-04-07 /pmc/articles/PMC10079314/ /pubmed/37334160 http://dx.doi.org/10.1016/j.gendis.2022.12.019 Text en © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Kumar, Sunny Basu, Malini Ghosh, Pratyasha Pal, Uttam Ghosh, Mrinal K. COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
title | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
title_full | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
title_fullStr | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
title_full_unstemmed | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
title_short | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
title_sort | covid-19 therapeutics: clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079314/ https://www.ncbi.nlm.nih.gov/pubmed/37334160 http://dx.doi.org/10.1016/j.gendis.2022.12.019 |
work_keys_str_mv | AT kumarsunny covid19therapeuticsclinicalapplicationofrepurposeddrugsandfuturisticstrategiesfortargetbaseddrugdiscovery AT basumalini covid19therapeuticsclinicalapplicationofrepurposeddrugsandfuturisticstrategiesfortargetbaseddrugdiscovery AT ghoshpratyasha covid19therapeuticsclinicalapplicationofrepurposeddrugsandfuturisticstrategiesfortargetbaseddrugdiscovery AT paluttam covid19therapeuticsclinicalapplicationofrepurposeddrugsandfuturisticstrategiesfortargetbaseddrugdiscovery AT ghoshmrinalk covid19therapeuticsclinicalapplicationofrepurposeddrugsandfuturisticstrategiesfortargetbaseddrugdiscovery |