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COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are continuously facing huge problems in the treatment of patients, as COVID-19-specific drugs are not available, hence the principle of drug repurposing serves as a one-and-only hope. Gl...

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Detalles Bibliográficos
Autores principales: Kumar, Sunny, Basu, Malini, Ghosh, Pratyasha, Pal, Uttam, Ghosh, Mrinal K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079314/
https://www.ncbi.nlm.nih.gov/pubmed/37334160
http://dx.doi.org/10.1016/j.gendis.2022.12.019
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author Kumar, Sunny
Basu, Malini
Ghosh, Pratyasha
Pal, Uttam
Ghosh, Mrinal K.
author_facet Kumar, Sunny
Basu, Malini
Ghosh, Pratyasha
Pal, Uttam
Ghosh, Mrinal K.
author_sort Kumar, Sunny
collection PubMed
description Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are continuously facing huge problems in the treatment of patients, as COVID-19-specific drugs are not available, hence the principle of drug repurposing serves as a one-and-only hope. Globally, the repurposing of many drugs is underway; few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical trials. Here in this review, our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs, the potential mechanism of actions, and the current clinical trial status of various drugs which are under repurposing since early 2020. At last, we briefly proposed the probable pharmacological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines.
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spelling pubmed-100793142023-04-07 COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery Kumar, Sunny Basu, Malini Ghosh, Pratyasha Pal, Uttam Ghosh, Mrinal K. Genes Dis Review Article Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are continuously facing huge problems in the treatment of patients, as COVID-19-specific drugs are not available, hence the principle of drug repurposing serves as a one-and-only hope. Globally, the repurposing of many drugs is underway; few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical trials. Here in this review, our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs, the potential mechanism of actions, and the current clinical trial status of various drugs which are under repurposing since early 2020. At last, we briefly proposed the probable pharmacological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines. Chongqing Medical University 2023-04-07 /pmc/articles/PMC10079314/ /pubmed/37334160 http://dx.doi.org/10.1016/j.gendis.2022.12.019 Text en © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Kumar, Sunny
Basu, Malini
Ghosh, Pratyasha
Pal, Uttam
Ghosh, Mrinal K.
COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
title COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
title_full COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
title_fullStr COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
title_full_unstemmed COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
title_short COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
title_sort covid-19 therapeutics: clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079314/
https://www.ncbi.nlm.nih.gov/pubmed/37334160
http://dx.doi.org/10.1016/j.gendis.2022.12.019
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