Incidence of Cardiovascular Disease After Atopic Dermatitis Development: A Nationwide, Population-Based Study

PURPOSE: Despite increasing evidence for the potential association between atopic dermatitis (AD) and cardiovascular diseases (CVDs), results have still remained controversial. Therefore, this study investigated the association between AD and subsequent CVDs in adults newly diagnosed with AD. METHODS: Datasets from the National Health Insurance Service-National Sample Cohort in South Korea from 2002 to 2015 were analyzed. The primary outcome was new-onset CVD, which included angina pectoris, myocardial infarction, stroke, or any revascularization procedure. The crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated in the AD group compared with the matched control group using the Cox proportional hazards regression models. RESULTS: A total of 40,512 individuals with AD were matched with 40,512 control subjects without AD. The overall incidence of CVDs was 2,235 (5.5%) and 1,640 (4.1%) in the AD and matched control groups, respectively. In the adjusted model, AD was associated with an increased risk of CVDs (HR, 1.42; 95% CI, 1.33–1.52), angina pectoris (adjusted HR, 1.49; 95% CI, 1.36–1.63), myocardial infarction (adjusted HR, 1.40; 95% CI, 1.15–1.70), ischemic stroke (adjusted HR, 1.34; 95% CI, 1.20–1.49), and hemorrhagic stroke (adjusted HR, 1.26; 95% CI, 1.05–1.52). Most of the subgroup and sensitivity analysis results were consistent with those of the main analysis. CONCLUSIONS: The current study found that adult patients newly diagnosed with AD were at significantly increased risk for subsequent CVDs, suggesting the need to consider early prevention strategies for CVDs targeting patients with AD.