Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia

Murine models offer a valuable tool to recapitulate genetically defined subtypes of AML, and to assess the potential of compound mutations and clonal evolution during disease progression. This is of particular importance for difficult to treat leukemias such as FLT3 internal tandem duplication (ITD)...

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Detalles Bibliográficos
Autores principales: Straube, Jasmin, Eifert, Theresa, Vu, Therese, Janardhanan, Yashaswini, Haldar, Rohit, von Eyss, Björn, Cooper, Leanne, Bruedigam, Claudia, Ling, Victoria Y., Cooper, Emily, Patch, Ann-Marie, Bullinger, Lars, Schnoeder, Tina M., Bywater, Megan, Heidel, Florian H., Lane, Steven W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079527/
https://www.ncbi.nlm.nih.gov/pubmed/36739348
http://dx.doi.org/10.1038/s41375-023-01832-0

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