Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia

Mitochondrial metabolism recently emerged as a critical dependency in acute myeloid leukemia (AML). The shape of mitochondria is tightly regulated by dynamin GTPase proteins, which drive opposing fusion and fission forces to consistently adapt bioenergetics to the cellular context. Here, we showed t...

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Detalles Bibliográficos
Autores principales: Larrue, Clement, Mouche, Sarah, Lin, Shan, Simonetta, Federico, Scheidegger, Nastassja K., Poulain, Laury, Birsen, Rudy, Sarry, Jean-Emmanuel, Stegmaier, Kimberly, Tamburini, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079528/
https://www.ncbi.nlm.nih.gov/pubmed/36739349
http://dx.doi.org/10.1038/s41375-023-01835-x

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