The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells

The transcription factor NFE2 is overexpressed in most patients with myeloproliferative neoplasms (MPN). Moreover, mutations in NFE2, found in a subset of MPN patients, strongly predispose for transformation to acute leukemia. Transgenic mice overexpressing NFE2 as well as mice harboring NFE2 mutati...

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Detalles Bibliográficos
Autores principales: Staehle, Anne Marie, Peeken, Jan Caspar, Vladimirov, Georg, Hoeness, Mirjam Elisabeth, Bojtine Kovacs, Sarolta, Karantzelis, Nikolaos, Gruender, Albert, Koellerer, Christoph, Jutzi, Jonas Samuel, Pahl, Heike Luise, Staehle, Hans Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079541/
https://www.ncbi.nlm.nih.gov/pubmed/36709354
http://dx.doi.org/10.1038/s41375-023-01826-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079541/
https://www.ncbi.nlm.nih.gov/pubmed/36709354
http://dx.doi.org/10.1038/s41375-023-01826-y

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