The selection of a hydrophobic 7-phenylbutyl-7-deazaadenine-modified DNA aptamer with high binding affinity for the Heat Shock Protein 70

Nucleic acids aptamers often fail to efficiently target some proteins because of the hydrophilic character of the natural nucleotides. Here we present hydrophobic 7-phenylbutyl-7-deaadenine-modified DNA aptamers against the Heat Shock Protein 70 that were selected via PEX and magnetic bead-based SEL...

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Detalles Bibliográficos
Autores principales: Mulholland, Catherine, Jestřábová, Ivana, Sett, Arghya, Ondruš, Marek, Sýkorová, Veronika, Manzanares, C. Lorena, Šimončík, Oliver, Muller, Petr, Hocek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079658/
https://www.ncbi.nlm.nih.gov/pubmed/37024672
http://dx.doi.org/10.1038/s42004-023-00862-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079658/
https://www.ncbi.nlm.nih.gov/pubmed/37024672
http://dx.doi.org/10.1038/s42004-023-00862-0

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