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All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals

Excitable cells can be stimulated or inhibited by optogenetics. Since optogenetic actuation regimes are often static, neurons and circuits can quickly adapt, allowing perturbation, but not true control. Hence, we established an optogenetic voltage-clamp (OVC). The voltage-indicator QuasAr2 provides...

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Detalles Bibliográficos
Autores principales: Bergs, Amelie C. F., Liewald, Jana F., Rodriguez-Rozada, Silvia, Liu, Qiang, Wirt, Christin, Bessel, Artur, Zeitzschel, Nadja, Durmaz, Hilal, Nozownik, Adrianna, Dill, Holger, Jospin, Maëlle, Vierock, Johannes, Bargmann, Cornelia I., Hegemann, Peter, Wiegert, J. Simon, Gottschalk, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10079764/
https://www.ncbi.nlm.nih.gov/pubmed/37024493
http://dx.doi.org/10.1038/s41467-023-37622-6